Name: Anti-EPB42 Antibody (CAB17481)
Brand: Cell Biology Antibodies 13
SKU: CAB17481
Availability: OutOfStock

Antibody Name:	Anti-EPB42 Antibody
Antibody SKU:	CAB17481
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 10-240 of human EPB42 (NP_001107606).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	A-549, 293T, Mouse liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 10-240 of human EPB42 (NP_001107606).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	CDFQ AARN NEEH HTKA LSSR RLFV RRGQ PFTI ILYF RAPV RAFL PALK KVAL TAQT GEQP SKIN RTQA TFPI SSLG DRKW WSAV VEER DAQS WTIS VTTP ADAV IGHY SLLL QVSG RKQL LLGQ FTLL FNPW NRED AVFL KNEA QRME YLLN QNGL IYLG TADC IQAE SWDF GQFE GDVI DLSL RLLS KDKQ VEKW SQPV HVAR VLGA LLHF LKEQ RVLP TPQT QATQ EGA
Gene ID:	2038
Uniprot:	P16452
Cellular Location:
Calculated MW:
Observed MW:	77kDa

Western blot - EPB42 Polyclonal Antibody (CAB17481)

Synonyms:

PA, SPH5, EPB42

Background:

Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Protein Function:	Epb4.2: Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Defects in EPB42 are the cause of spherocytosis type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 15q15-q21 Cellular Component: cortical cytoskeleton; cytoskeleton; plasma membrane Molecular Function:protein binding; structural constituent of cytoskeleton; protein-glutamine gamma-glutamyltransferase activity; ATP binding Biological Process: spleen development; regulation of cell shape; iron ion homeostasis; erythrocyte maturation; hemoglobin metabolic process; cell morphogenesis; peptide cross-linking Disease: Spherocytosis, Type 5
NCBI Summary:	Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P16452
NCBI GenInfo Identifier:	215274164
NCBI Gene ID:	2038
NCBI Accession:	P16452.3
UniProt Secondary Accession:	P16452,Q4KKX0, Q4VB97,
UniProt Related Accession:	P16452
Molecular Weight:	69,455 Da
NCBI Full Name:	Erythrocyte membrane protein band 4.2
NCBI Synonym Full Names:	erythrocyte membrane protein band 4.2
NCBI Official Symbol:	EPB42
NCBI Official Synonym Symbols:	PA; SPH5
NCBI Protein Information:	erythrocyte membrane protein band 4.2
UniProt Protein Name:	Erythrocyte membrane protein band 4.2
Protein Family:	Erythrocyte membrane protein
UniProt Gene Name:	EPB42
UniProt Entry Name:	EPB42_HUMAN