Cell Death Antibodies 1

Anti-EPB41L3 Antibody (CAB12759)

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SKU:
CAB12759
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-EPB41L3 Antibody
Antibody SKU:CAB12759
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 656-865 of human EPB41L3 (NP_001268463.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 656-865 of human EPB41L3 (NP_001268463.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GDAA AQPA FTGI KGKE GSAL TEGA KEEG GEEV AKAV LEQE ETAA ASRE RQEE QSAA IHIS ETLE QKPH FESS TVKT ETIS FGSV SPGG VKLE ISTK EVPV VHTE TKTI TYES SQVD PGTD LEPG VLMS AQTI TSET TSTT TTTH ITKT VKGG ISET RIEK RIVI TGDA DIDH DQAL AQAI KEAK EQHP DMSV TKVV VHKE TEIT PEDG ED
Gene ID:23136
Uniprot:Q9Y2J2
Cellular Location:Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton
Calculated MW:69kDa/96kDa/98kDa/120kDa
Observed MW:121kDa
Synonyms:EPB41L3, 4.1B, DAL-1, DAL1
Background:
UniProt Protein Function:EPB41L3: a possible tumor suppressor protein that plays a role in cell adhesion and apoptosis. Critical growth regulator in the pathogenesis of meningiomas. Three alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 18p11.31

Cellular Component: axolemma; cytoskeleton; cytosol; intercellular junction; paranode region of axon; plasma membrane

Molecular Function:protein binding; structural constituent of cytoskeleton

Biological Process: actomyosin structure organization and biogenesis; cortical cytoskeleton organization and biogenesis; cytoskeletal anchoring; myelin maintenance; neurite morphogenesis; paranodal junction assembly; regulation of cell shape

UniProt Code:Q9Y2J2
NCBI GenInfo Identifier:17433099
NCBI Gene ID:23136
NCBI Accession:Q9Y2J2.2
UniProt Secondary Accession:Q9Y2J2,O95713, Q9BRP5, B7Z4I5, F5GX05,
UniProt Related Accession:Q9Y2J2
Molecular Weight:121kDa
NCBI Full Name:Band 4.1-like protein 3
NCBI Synonym Full Names:erythrocyte membrane protein band 4.1 like 3
NCBI Official Symbol:EPB41L3  
NCBI Official Synonym Symbols:4.1B; DAL1; DAL-1  
NCBI Protein Information:band 4.1-like protein 3
UniProt Protein Name:Band 4.1-like protein 3
UniProt Synonym Protein Names:4.1B; Differentially expressed in adenocarcinoma of the lung protein 1; DAL-1
Protein Family:Band 4.1-like protein
UniProt Gene Name:EPB41L3  
Anti-EPB41L3 Antibody (CAB12759)Western blot analysis of extracts of various cell lines, using EPB41L3 antibody (CAB12759) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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