Cell Cycle Antibodies 1
Anti-EPB41 Antibody (CAB2490)
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- SKU:
- CAB2490
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-EPB41 Antibody |
| Antibody SKU: | CAB2490 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-500 of human EPB41 (NP_001159478.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse brain, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-500 of human EPB41 (NP_001159478.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MHCK VSLL DDTV YECV VEKH AKGQ DLLK RVCE HLNL LEED YFGL AIWD NATS KTWL DSAK EIKK QVRG VPWN FTFN VKFY PPDP AQLT EDIT RYYL CLQL RQDI VAGR LPCS FATL ALLG SYTI QSEL GDYD PELH GVDY VSDF KLAP NQTK ELEE KVME LHKS YRSM TPAQ ADLE FLEN AKKL SMYG VDLH KAKD LEGV DIIL GVCS SGLL VYKD KLRI NRFP WPKV LKIS YKRS SFFI KIRP GEQE QYES TIGF KLPS YRAA KKLW KVCV EHHT FFRL TSTD TIPK SKF |
| Gene ID: | 2035 |
| Uniprot: | P11171 |
| Cellular Location: | Cytoplasm, Nucleus, cell cortex, cytoskeleton |
| Calculated MW: | 63kDa/66kDa/71kDa/81kDa/86kDa/93kDa/97kDa |
| Observed MW: | 90-97kDa |
| Synonyms: | EPB41, 4.1R, EL1, HE |
| Background: | The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. |
| NCBI Summary: | The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009] |
| UniProt Code: | P11171 |
| NCBI GenInfo Identifier: | 90101808 |
| NCBI Gene ID: | 2035 |
| NCBI Accession: | P11171.4 |
| UniProt Secondary Accession: | P11171,P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578 Q9Y579, B1ALH8, B1ALH9, D3DPM9, D3DPN0, |
| UniProt Related Accession: | P11171 |
| Molecular Weight: | 97kDa |
| NCBI Full Name: | Protein 4.1 |
| NCBI Synonym Full Names: | erythrocyte membrane protein band 4.1 |
| NCBI Official Symbol: | EPB41 |
| NCBI Official Synonym Symbols: | HE; EL1; 4.1R |
| NCBI Protein Information: | protein 4.1 |
| UniProt Protein Name: | Protein 4.1 |
| UniProt Synonym Protein Names: | 4.1R; Band 4.1; EPB4.1 |
| Protein Family: | Erythroid protein |
| UniProt Gene Name: | EPB41 |
 | Western blot analysis of extracts of various cell lines, using EPB41 antibody (CAB2490) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using EPB41 antibody (CAB2490) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using EPB41 antibody (CAB2490) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using EPB41 antibody (CAB2490). Blue: DAPI for nuclear staining. |
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