Cardiovascular Antibodies
Anti-Epac1 Antibody (CAB4149)
- SKU:
- CAB4149
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-Epac1 Antibody |
| Antibody SKU: | CAB4149 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Epac1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse brain, Mouse kidney, Rat brain |
| Immunogen: | A synthesized peptide derived from human Epac1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10411 |
| Uniprot: | O95398 |
| Cellular Location: | |
| Calculated MW: | 104kDa |
| Observed MW: | 100KDa |
| Synonyms: | CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910 |
| Background: |
| UniProt Protein Function: | Epac1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEFs, misc.; GEFs Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: membrane; plasma membrane; endomembrane system; cAMP-dependent protein kinase complex Molecular Function:Rap guanyl-nucleotide exchange factor activity; protein binding; guanyl-nucleotide exchange factor activity; cAMP-dependent protein kinase regulator activity; cAMP binding Biological Process: positive regulation of syncytium formation by plasma membrane fusion; platelet activation; signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; cell proliferation; positive regulation of angiogenesis; cAMP-mediated signaling; positive regulation of stress fiber formation; energy reserve metabolic process; positive regulation of cAMP catabolic process; angiogenesis; blood coagulation; regulation of protein kinase activity; regulation of insulin secretion; Rap protein signal transduction |
| UniProt Code: | O95398 |
| NCBI GenInfo Identifier: | 317373593 |
| NCBI Gene ID: | 10411 |
| NCBI Accession: | O95398.6 |
| UniProt Related Accession: | O95398 |
| Molecular Weight: | |
| NCBI Full Name: | Rap guanine nucleotide exchange factor 3 |
| NCBI Synonym Full Names: | Rap guanine nucleotide exchange factor 3 |
| NCBI Official Symbol: | RAPGEF3 |
| NCBI Official Synonym Symbols: | EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI |
| NCBI Protein Information: | rap guanine nucleotide exchange factor 3 |
| UniProt Protein Name: | Rap guanine nucleotide exchange factor 3 |
| UniProt Synonym Protein Names: | Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I |
| UniProt Gene Name: | RAPGEF3 |
| UniProt Entry Name: | RPGF3_HUMAN |
 | Western blot - Epac1 Rabbit mAb (CAB4149) |
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