Cell Biology Antibodies 18
Anti-EOMES Antibody (CAB18222)
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- SKU:
- CAB18222
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-EOMES Antibody |
| Antibody SKU: | CAB18222 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human EOMES. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human EOMES. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8320 |
| Uniprot: | O95936 |
| Cellular Location: | |
| Calculated MW: | 73kDa |
| Observed MW: | Refer to figures |
| Synonyms: | TBR2, EOMES |
| Background: | This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. |
| NCBI Summary: | This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
| UniProt Code: | O95936 |
| NCBI GenInfo Identifier: | 229462982 |
| NCBI Gene ID: | 8320 |
| NCBI Accession: | O95936.3 |
| UniProt Secondary Accession: | O95936,Q8TAZ2, Q9UPM7, B7Z4I2, B7ZA51, G3XAI5, |
| UniProt Related Accession: | O95936 |
| Molecular Weight: | 74,852 Da |
| NCBI Full Name: | Eomesodermin homolog |
| NCBI Synonym Full Names: | eomesodermin |
| NCBI Official Symbol: | EOMES |
| NCBI Official Synonym Symbols: | TBR2 |
| NCBI Protein Information: | eomesodermin homolog |
| UniProt Protein Name: | Eomesodermin homolog |
| UniProt Synonym Protein Names: | T-box brain protein 2; T-brain-2; TBR-2 |
| Protein Family: | Eomesodermin |
| UniProt Gene Name: | EOMES |
| UniProt Entry Name: | EOMES_HUMAN |
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