Cell Biology Antibodies 11
Anti-ENTPD5 Antibody (CAB8108)
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- SKU:
- CAB8108
- Product Type:
- Antibody
- Applications:
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | ENTPD5 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8108 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 149-428 of human ENTPD5 (NP_001240.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 149-428 of human ENTPD5 (NP_001240.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KEIF RKSP FLVP KGSV SIMD GSDE GILA WVTV NFLT GQLH GHRQ ETVG TLDL GGAS TQIT FLPQ FEKT LEQT PRGY LTSF EMFN STYK LYTH SYLG FGLK AARL ATLG ALET EGTD GHTF RSAC LPRW LEAE WIFG GVKY QYGG NQEG EVGF EPCY AEVL RVVR GKLH QPEE VQRG SFYA FSYY YDRA VDTD MIDY EKGG ILKV EDFE RKAR EVCD NLEN FTSG SPFL CMDL SYIT ALLK DGFG FADS TVLQ LTKK VNNI ETGW ALGA TFHL LQSL GISH |
| Gene ID: | 957 |
| Uniprot: | O75356 |
| Cellular Location: | Endoplasmic reticulum, Secreted |
| Calculated MW: | 47kDa |
| Observed MW: |
| Synonyms: | ENTPD5, CD39L4, NTPDase-5, PCPH |
| Background: | The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. |
| UniProt Protein Function: | ENTPD5: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. Belongs to the GDA1/CD39 NTPase family. |
| UniProt Protein Details: | Protein type:Hydrolase; Nucleotide Metabolism - pyrimidine; Oncoprotein; EC 3.6.1.6; EC 3.6.1.42; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 14q24 Cellular Component: endoplasmic reticulum Molecular Function:guanosine-diphosphatase activity; protein binding; uridine-diphosphatase activity Biological Process: 'de novo' posttranslational protein folding; ATP metabolic process; cell growth; cell proliferation; positive regulation of glycolysis; protein amino acid N-linked glycosylation; regulation of phosphoinositide 3-kinase cascade |
| NCBI Summary: | The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009] |
| UniProt Code: | O75356 |
| NCBI GenInfo Identifier: | 18202142 |
| NCBI Gene ID: | 957 |
| NCBI Accession: | O75356.1 |
| UniProt Secondary Accession: | O75356,Q96RX0, A1L4C5, |
| UniProt Related Accession: | O75356 |
| Molecular Weight: | 47,517 Da |
| NCBI Full Name: | Ectonucleoside triphosphate diphosphohydrolase 5 |
| NCBI Synonym Full Names: | ectonucleoside triphosphate diphosphohydrolase 5 |
| NCBI Official Symbol: | ENTPD5 |
| NCBI Official Synonym Symbols: | PCPH; CD39L4; NTPDase-5 |
| NCBI Protein Information: | ectonucleoside triphosphate diphosphohydrolase 5 |
| UniProt Protein Name: | Ectonucleoside triphosphate diphosphohydrolase 5 |
| UniProt Synonym Protein Names: | CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5 (EC:3.6.1.42); GDPase ENTPD5; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5 |
| Protein Family: | Ectonucleoside triphosphate diphosphohydrolase |
| UniProt Gene Name: | ENTPD5 |
| UniProt Entry Name: | ENTP5_HUMAN |
 | Immunofluorescence analysis of U2OS cells using ENTPD5 antibody (CAB8108) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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