Anti-ENTPD5 Antibody (CAB19647)
- SKU:
- CAB19647
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CD39L4
- Synonyms:
- NTPDase-5
- Synonyms:
- PCPH
- Research Area:
- Cell Biology
Description
| Product Name: | ENTPD5 Rabbit mAb |
| Product Code: | CAB19647 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CD39L4, NTPDase-5, PCPH |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ENTPD5 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:1000 - 1:3000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, PC-3, Mouse liver, Rat liver, Rat kidney |
| Immunogen: | A synthesized peptide derived from human ENTPD5 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 957 |
| Uniprot: | O75356 |
| Calculated MW: | 47kDa |
| Observed MW: | 48KDa |
| UniProt Protein Function: | ENTPD5: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. Belongs to the GDA1/CD39 NTPase family. |
| UniProt Protein Details: | Protein type:Hydrolase; Nucleotide Metabolism - pyrimidine; Oncoprotein; EC 3.6.1.6; EC 3.6.1.42; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 14q24 Cellular Component: endoplasmic reticulum Molecular Function:guanosine-diphosphatase activity; protein binding; uridine-diphosphatase activity Biological Process: 'de novo' posttranslational protein folding; ATP metabolic process; cell growth; cell proliferation; positive regulation of glycolysis; protein amino acid N-linked glycosylation; regulation of phosphoinositide 3-kinase cascade |
| NCBI Summary: | The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009] |
| UniProt Code: | O75356 |
| NCBI GenInfo Identifier: | 18202142 |
| NCBI Gene ID: | 957 |
| NCBI Accession: | O75356.1 |
| UniProt Secondary Accession: | O75356,Q96RX0, A1L4C5, |
| UniProt Related Accession: | O75356 |
| Molecular Weight: | 47,517 Da |
| NCBI Full Name: | Ectonucleoside triphosphate diphosphohydrolase 5 |
| NCBI Synonym Full Names: | ectonucleoside triphosphate diphosphohydrolase 5 |
| NCBI Official Symbol: | ENTPD5 |
| NCBI Official Synonym Symbols: | PCPH; CD39L4; NTPDase-5 |
| NCBI Protein Information: | ectonucleoside triphosphate diphosphohydrolase 5 |
| UniProt Protein Name: | Ectonucleoside triphosphate diphosphohydrolase 5 |
| UniProt Synonym Protein Names: | CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5 (EC:3.6.1.42); GDPase ENTPD5; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5 |
| Protein Family: | Ectonucleoside triphosphate diphosphohydrolase |
| UniProt Gene Name: | ENTPD5 |
| UniProt Entry Name: | ENTP5_HUMAN |
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