Cell Biology Antibodies 9
Anti-ENTPD1/CD39 Antibody (CAB3778)
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- SKU:
- CAB3778
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ENTPD1/CD39 Antibody |
| Antibody SKU: | CAB3778 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ENTPD1/CD39 (NP_001157655.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:1000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, HeLa, A-549, LO2, HL-60, MCF7, Mouse lung, Mouse spleen, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ENTPD1/CD39 (NP_001157655.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MESE ELAD RVLD VVER SLSN YPFD FQGA RIIT GQEE GAYG WITI NYLL GKFS QKTR WFSI VPYE TNNQ ETFG ALDL GGAS TQVT FVPQ NQTI ESPD NALQ FRLY GKDY NVYT HSFL CYGK DQAL WQKL AKDI QVAS NEIL RDPC FHPG YKKV VNVS DLYK TPCT KRFE MTLP FQQF EIQG |
| Gene ID: | 953 |
| Uniprot: | P49961 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 34kDa/42kDa/46kDa/57kDa/58kDa/59kDa |
| Observed MW: | 65kDa |
| Synonyms: | ENTPD1, ATPDase, CD39, NTPDase-1, SPG64 |
| Background: | The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. |
| NCBI Summary: | The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P49961 |
| NCBI GenInfo Identifier: | 1705710 |
| NCBI Gene ID: | 953 |
| NCBI Accession: | P49961.1 |
| UniProt Secondary Accession: | P49961,Q5T561, Q5T562, Q86VV3, Q9UQQ9, Q9Y3Q9, A9Z1X8 B4DWB9, B4E1X1, B7Z599, G3XAF6, |
| UniProt Related Accession: | P49961 |
| Molecular Weight: | 59,325 Da |
| NCBI Full Name: | Ectonucleoside triphosphate diphosphohydrolase 1 |
| NCBI Synonym Full Names: | ectonucleoside triphosphate diphosphohydrolase 1 |
| NCBI Official Symbol: | ENTPD1 |
| NCBI Official Synonym Symbols: | CD39; SPG64; ATPDase; NTPDase-1 |
| NCBI Protein Information: | ectonucleoside triphosphate diphosphohydrolase 1 |
| UniProt Protein Name: | Ectonucleoside triphosphate diphosphohydrolase 1 |
| UniProt Synonym Protein Names: | Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; CD_antigen: CD39 |
| UniProt Gene Name: | ENTPD1 |
| UniProt Entry Name: | ENTP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ENTPD1/CD39 antibody (CAB3778) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of Raw264.7 cells using ENTPD1/CD39 Polyclonal Antibody (CAB3778) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of THP-1 cells using ENTPD1/CD39 Polyclonal Antibody (CAB3778) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of human placenta using ENTPD1/CD39 Polyclonal Antibody (CAB3778) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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