Cell Cycle Antibodies 1
Anti-ENSA Antibody (CAB15665)
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- SKU:
- CAB15665
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-ENSA Antibody |
| Antibody SKU: | CAB15665 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ENSA (NP_996929.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain, Mouse liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ENSA (NP_996929.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGG LGCD VCYW FVED TQEK EGIL PERA EEAK LKAK YPSL GQKP GGSD FLMK RLQK GQKY FDSG DYNM AKAK MKNK QLPS AGPD KNLV TGDH IPTP QDLP |
| Gene ID: | 2029 |
| Uniprot: | O43768 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 11kDa/12kDa/13kDa/14kDa/15kDa |
| Observed MW: | 13kDa |
| Synonyms: | ENSA, ARPP-19e |
| Background: | The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| UniProt Protein Function: | ENSA: a cytoplasmic, highly conserved cAMP-regulated phosphoprotein (ARPP) and regulator of ATP-sensitive potassium (KATP) channels. An endogenous ligand for the sulfonylurea receptor, ABCC8, the regulatory subunit of the KATP channel located on the plasma membrane of pancreatic beta cells. Modulates insulin secretion through the interaction with ABCC8, and may be associated with type 2 diabetes. Eight alternatively spliced isoforms have been observed. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: nucleoplasm; cytoplasm Molecular Function:phosphatase inhibitor activity; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity; protein phosphatase inhibitor activity; potassium channel inhibitor activity; ion channel inhibitor activity; receptor binding Biological Process: mitosis; transport; regulation of catalytic activity; cell division; negative regulation of catalytic activity; response to glucose stimulus; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of insulin secretion; response to nutrient |
| NCBI Summary: | The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43768 |
| NCBI GenInfo Identifier: | 2764974 |
| NCBI Gene ID: | 2029 |
| NCBI Accession: | CAA68180.1 |
| UniProt Secondary Accession: | O43768,Q5T5H2, Q68D48, Q6FHW0, Q6IAM4, Q6NUL2, Q6VUC6 Q6VUC7, Q6VUC8, Q6VUC9, A8K1Z9, E9PB69, |
| UniProt Related Accession: | O43768 |
| Molecular Weight: | 14,868 Da |
| NCBI Full Name: | alpha endosulfine |
| NCBI Synonym Full Names: | endosulfine alpha |
| NCBI Official Symbol: | ENSA |
| NCBI Official Synonym Symbols: | ARPP-19e |
| NCBI Protein Information: | alpha-endosulfine |
| UniProt Protein Name: | Alpha-endosulfine |
| UniProt Synonym Protein Names: | ARPP-19e |
| Protein Family: | Alpha-endosulfine |
| UniProt Gene Name: | ENSA |
| UniProt Entry Name: | ENSA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ENSA antibody (CAB15665) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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