Metabolism Antibodies 2

Anti-ENPP7 Antibody (CAB2912)

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SKU:
CAB2912

Description

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Antibody Name:Anti-ENPP7 Antibody
Antibody SKU:CAB2912
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human ENPP7
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HepG2
Immunogen:A synthetic peptide of human ENPP7
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:339221
Uniprot:Q6UWV6
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:51kDa
Observed MW:51kDa
Synonyms:ENPP7, ALK-SMase, E-NPP 7, NPP-7, NPP7, E-NPP7
Background:The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity.
UniProt Protein Function:ENPP7: Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
UniProt Protein Details:

Protein type:Phosphodiesterase; Lipid Metabolism - sphingolipid; Cell cycle regulation; DNA replication; Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.4.12

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: Golgi apparatus; microvillus; membrane; integral to membrane; plasma membrane

Molecular Function:sphingomyelin phosphodiesterase activity

Biological Process: negative regulation of cell proliferation; sphingomyelin metabolic process; sphingolipid metabolic process; negative regulation of DNA replication; glycosphingolipid metabolic process; sphingomyelin catabolic process

UniProt Code:Q6UWV6
NCBI GenInfo Identifier:134047772
NCBI Gene ID:339221
NCBI Accession:Q6UWV6.3
UniProt Secondary Accession:Q6UWV6,Q6ZTS5, Q8IUS8,
UniProt Related Accession:Q6UWV6
Molecular Weight:458
NCBI Full Name:Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
NCBI Synonym Full Names:ectonucleotide pyrophosphatase/phosphodiesterase 7
NCBI Official Symbol:ENPP7  
NCBI Official Synonym Symbols:NPP7; NPP-7; E-NPP 7; ALK-SMase  
NCBI Protein Information:ectonucleotide pyrophosphatase/phosphodiesterase family member 7; ENPP7; alkaline sphingomyelinase; intestinal alkaline sphingomyelinase; alkaline sphingomyelin phosphodiesterase
UniProt Protein Name:Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
UniProt Synonym Protein Names:Alkaline sphingomyelin phosphodiesterase; Intestinal alkaline sphingomyelinase; Alk-SMase
Protein Family:Ectonucleotide pyrophosphatase/phosphodiesterase family
UniProt Gene Name:ENPP7  
UniProt Entry Name:ENPP7_HUMAN
Anti-ENPP7 Antibody (CAB2912)Western blot analysis of extracts of HepG2 cells, using ENPP7 antibody (CAB2912) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
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