Metabolism Antibodies 2
Anti-ENPP7 Antibody (CAB2912)
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- SKU:
- CAB2912
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-ENPP7 Antibody |
| Antibody SKU: | CAB2912 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human ENPP7 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2 |
| Immunogen: | A synthetic peptide of human ENPP7 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 339221 |
| Uniprot: | Q6UWV6 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 51kDa |
| Observed MW: | 51kDa |
| Synonyms: | ENPP7, ALK-SMase, E-NPP 7, NPP-7, NPP7, E-NPP7 |
| Background: | The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. |
| UniProt Protein Function: | ENPP7: Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. |
| UniProt Protein Details: | Protein type:Phosphodiesterase; Lipid Metabolism - sphingolipid; Cell cycle regulation; DNA replication; Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.4.12 Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: Golgi apparatus; microvillus; membrane; integral to membrane; plasma membrane Molecular Function:sphingomyelin phosphodiesterase activity Biological Process: negative regulation of cell proliferation; sphingomyelin metabolic process; sphingolipid metabolic process; negative regulation of DNA replication; glycosphingolipid metabolic process; sphingomyelin catabolic process |
| UniProt Code: | Q6UWV6 |
| NCBI GenInfo Identifier: | 134047772 |
| NCBI Gene ID: | 339221 |
| NCBI Accession: | Q6UWV6.3 |
| UniProt Secondary Accession: | Q6UWV6,Q6ZTS5, Q8IUS8, |
| UniProt Related Accession: | Q6UWV6 |
| Molecular Weight: | 458 |
| NCBI Full Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 |
| NCBI Synonym Full Names: | ectonucleotide pyrophosphatase/phosphodiesterase 7 |
| NCBI Official Symbol: | ENPP7 |
| NCBI Official Synonym Symbols: | NPP7; NPP-7; E-NPP 7; ALK-SMase |
| NCBI Protein Information: | ectonucleotide pyrophosphatase/phosphodiesterase family member 7; ENPP7; alkaline sphingomyelinase; intestinal alkaline sphingomyelinase; alkaline sphingomyelin phosphodiesterase |
| UniProt Protein Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 |
| UniProt Synonym Protein Names: | Alkaline sphingomyelin phosphodiesterase; Intestinal alkaline sphingomyelinase; Alk-SMase |
| Protein Family: | Ectonucleotide pyrophosphatase/phosphodiesterase family |
| UniProt Gene Name: | ENPP7 |
| UniProt Entry Name: | ENPP7_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using ENPP7 antibody (CAB2912) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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