Metabolism Antibodies 1

Anti-ENPP6 Antibody (CAB12290)

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SKU:
CAB12290
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-ENPP6 Antibody
Antibody SKU:CAB12290
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 91-440 of human ENPP6 (NP_699174.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 91-440 of human ENPP6 (NP_699174.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GNYM WDPT TNKS FDIG VNKD SLMP LWWN GSEP LWVT LTKA KRKV YMYY WPGC EVEI LGVR PTYC LEYK NVPT DINF ANAV SDAL DSFK SGRA DLAA IYHE RIDV EGHH YGPA SPQR KDAL KAVD TVLK YMTK WIQE RGLQ DRLN VIIF SDHG MTDI FWMD KVIE LNKY ISLN DLQQ VKDR GPVV SLWP APGK HSEI YNKL STVE HMTV YEKE AIPS RFYY KKGK FVSP LTLV ADEG WFIT ENRE MLPF WMNS TGRR EGWQ RGWH GYDN ELMD MRGI FLAF GPDF KSNF RAAP IRSV DVYN VMCN VVGI TPLP NNGS WSRV MCML KGRA STAP PVWP SHCA LALI LLFL LA
Gene ID:133121
Uniprot:Q6UWR7
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:50kDa
Observed MW:50kDa
Synonyms:ENPP6, NPP6
Background:
UniProt Protein Function:ENPP6: Choline-specific glycerophosphodiester phosphodiesterase. Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p- nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
UniProt Protein Details:

Protein type:EC 3.1.4.38; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Lipid Metabolism - ether lipid; Phosphodiesterase

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: extracellular region; plasma membrane

Molecular Function:glycerophosphocholine cholinephosphodiesterase activity; phosphoric diester hydrolase activity; glycerophosphodiester phosphodiesterase activity

Biological Process: choline metabolic process; lipid metabolic process; lipid catabolic process

UniProt Code:Q6UWR7
NCBI GenInfo Identifier:108935979
NCBI Gene ID:133121
NCBI Accession:Q6UWR7.2
UniProt Secondary Accession:Q6UWR7,Q4W5Q1, Q96M57,
UniProt Related Accession:Q6UWR7
Molecular Weight:50,241 Da
NCBI Full Name:Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
NCBI Synonym Full Names:ectonucleotide pyrophosphatase/phosphodiesterase 6
NCBI Official Symbol:ENPP6  
NCBI Official Synonym Symbols:NPP6  
NCBI Protein Information:ectonucleotide pyrophosphatase/phosphodiesterase family member 6; B830047L21Rik; E-NPP 6; GPC-Cpde; NPP-6; choline-specific glycerophosphodiester phosphodiesterase; glycerophosphocholine cholinephosphodiesterase
UniProt Protein Name:Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
UniProt Synonym Protein Names:Choline-specific glycerophosphodiester phosphodiesterase; Glycerophosphocholine cholinephosphodiesterase; GPC-Cpde
Protein Family:Ectonucleotide pyrophosphatase/phosphodiesterase family
UniProt Gene Name:ENPP6  
UniProt Entry Name:ENPP6_HUMAN
Anti-ENPP6 Antibody (CAB12290)Western blot analysis of extracts of various cell lines, using ENPP6 antibody (CAB12290) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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