Cell Biology Antibodies 15

Anti-Enpp1 Antibody (CAB17876)

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SKU:
CAB17876
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Enpp1 Antibody
Antibody SKU:CAB17876
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 580-730 of mouse Enpp1 (NP_032839.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, 293T, Mouse kidney, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 580-730 of mouse Enpp1 (NP_032839.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PIYN PSHP KEEG FLSQ CPIK STSN DLGC TCDP WIVP IKDF EKQL NLTT EDDD IYHM TVPY GRPR ILLK QHRV CLLQ QQQF LTGY SLDL LMPL WASY TFLS NDQF SRDD FSNC LYQD LRIP LSPV HKCS YYKS NSKL SYGF LTPP RLNR VSN
Gene ID:18605
Uniprot:G3X9S2
Cellular Location:
Calculated MW:103kDa
Observed MW:120kDa/170kDa
Anti-Enpp1 Antibody (CAB17876)Western blot - Enpp1 Rabbit pAb (CAB17876)
Synonyms:Pca, ttw, twy, M6S1, NPP1, Npps, PC-1, Ly-41, Pca-1, Pdnp1, C76301, CD203c, E-NPP1, E-NPP 1, AI428932, 4833416E15Rik, Enpp1
Background:This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms.
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