Cell Biology Antibodies 10
Anti-ENOX2 Antibody (CAB7063)
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- SKU:
- CAB7063
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ENOX2 Antibody |
| Antibody SKU: | CAB7063 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 411-610 of human ENOX2 (NP_872114.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, THP-1, SW480, Jurkat, SKOV3, Mouse liver, Mouse kidney, Mouse ovary, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 411-610 of human ENOX2 (NP_872114.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AEAL KEEN DSLR WQLD AYRN EVEL LKQE QGKV HRED DPNK EQQL KLLQ QALQ GMQQ HLLK VQEE YKKK EAEL EKLK DDKL QVEK MLEN LKEK ESCA SRLC ASNQ DSEY PLEK TMNS SPIK SERE ALLV GIIS TFLH VHPF GASI EYIC SYLH RLDN KICT SDVE CLMG RLQH TFKQ EMTG VGAS LEKR WKFC GFEG LKLT |
| Gene ID: | 10495 |
| Uniprot: | Q16206 |
| Cellular Location: | Cell membrane, Secreted, extracellular space |
| Calculated MW: | 66kDa/70kDa |
| Observed MW: | 70kDa |
| Synonyms: | ENOX2, APK1, COVA1, tNOX |
| Background: | This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ENOX2: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Belongs to the ENOX family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell surface; Cytoskeletal; EC 1.-.-.-; Oxidoreductase Chromosomal Location of Human Ortholog: Xq26.1 Cellular Component: cytosol; external side of plasma membrane Molecular Function:protein disulfide oxidoreductase activity Biological Process: ultradian rhythm |
| NCBI Summary: | This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q16206 |
| NCBI GenInfo Identifier: | 32528293 |
| NCBI Gene ID: | 10495 |
| NCBI Accession: | NP_006366.2 |
| UniProt Secondary Accession: | Q16206,Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82, A8K197 A8K1C2, |
| UniProt Related Accession: | Q16206 |
| Molecular Weight: | 66,621 Da |
| NCBI Full Name: | ecto-NOX disulfide-thiol exchanger 2 isoform a |
| NCBI Synonym Full Names: | ecto-NOX disulfide-thiol exchanger 2 |
| NCBI Official Symbol: | ENOX2 |
| NCBI Official Synonym Symbols: | APK1; tNOX; COVA1 |
| NCBI Protein Information: | ecto-NOX disulfide-thiol exchanger 2 |
| UniProt Protein Name: | Ecto-NOX disulfide-thiol exchanger 2 |
| UniProt Synonym Protein Names: | APK1 antigen; Cytosolic ovarian carcinoma antigen 1; Tumor-associated hydroquinone oxidase; tNOX |
| Protein Family: | Ecto-NOX disulfide-thiol exchanger |
| UniProt Gene Name: | ENOX2 |
 | Western blot analysis of extracts of various cell lines, using ENOX2 antibody (CAB7063) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunofluorescence analysis of C6 cells using ENOX2 antibody (CAB7063) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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