Metabolism Antibodies 3
Anti-ENO1 Antibody (CAB11448)
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- SKU:
- CAB11448
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-ENO1 Antibody |
| Antibody SKU: | CAB11448 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ENO1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF7, RD, Mouse brain, Mouse spleen, Mouse kidney, Rat brain, Rat spleen, Rat kidney |
| Immunogen: | A synthesized peptide derived from human ENO1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2023 |
| Uniprot: | P06733 |
| Cellular Location: | |
| Calculated MW: | 47kDa |
| Observed MW: | 47KDa |
 | Western blot - ENO1 Rabbit mAb (CAB11448) |
| Synonyms: | ENO1L1, HEL-S-17, MPB1, NNE, PPH |
| Background: | This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011] |
| UniProt Protein Function: | ENO1: an abundant cytoplasmic enzyme with 2-phospho-D-glycerate hydro-lyase activity. A target of excess protein nitration in Alzheimer disease (AD) brain. Tau-crystallin, a structural lens protein, is produced from an alternative translation start in the enolase gene. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; EC 4.2.1.11; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lyase Chromosomal Location of Human Ortholog: 1p36.2 Cellular Component: cytoplasm; cytosol; extracellular space; M band; membrane; nucleus; phosphopyruvate hydratase complex; plasma membrane Molecular Function:DNA binding; GTPase binding; magnesium ion binding; phosphopyruvate hydratase activity; protein binding; transcription corepressor activity; transcription factor activity Biological Process: carbohydrate metabolic process; gluconeogenesis; glucose metabolic process; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; response to virus; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P06733 |
| NCBI GenInfo Identifier: | 119339 |
| NCBI Gene ID: | 2023 |
| NCBI Accession: | P06733.2 |
| UniProt Secondary Accession: | P06733,P22712, Q16704, Q4TUS4, Q53FT9, Q53HR3, Q658M5 Q6GMP2, Q71V37, Q7Z3V6, Q8WU71, B2RD59, |
| UniProt Related Accession: | P06733 |
| Molecular Weight: | 36,928 Da |
| NCBI Full Name: | Alpha-enolase |
| NCBI Synonym Full Names: | enolase 1, (alpha) |
| NCBI Official Symbol: | ENO1 |
| NCBI Official Synonym Symbols: | NNE; PPH; MPB1; ENO1L1; HEL-S-17 |
| NCBI Protein Information: | alpha-enolase; c-myc promoter-binding protein-1 |
| UniProt Protein Name: | Alpha-enolase |
| UniProt Synonym Protein Names: | 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein |
| UniProt Gene Name: | ENO1 |
| UniProt Entry Name: | ENOA_HUMAN |
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