Cell Biology Antibodies 7

Anti-EMP2 Antibody (CAB16327)

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SKU:
CAB16327
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-EMP2 Antibody
Antibody SKU:CAB16327
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human EMP2 (NP_001415.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human EMP2 (NP_001415.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VIND SFQE YSTL QAVQ ATMI LSTI LCCI AFFI FVLQ LFRL KQGE RFVL TSII QLMS CLCV MIAA SIYT DRRE DIHD KNAK FYPV TREG SYGY SYIL AWVA F
Gene ID:2013
Uniprot:P54851
Cellular Location:
Calculated MW:19kDa
Observed MW:Refer to figures
Synonyms:EMP2, XMP
Background:This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10).
UniProt Protein Function:EMP2: Belongs to the PMP-22/EMP/MP20 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: apical part of cell; caveola; cell surface; cytoplasm; cytoplasmic vesicle; Golgi apparatus; lipid raft; nucleus; plasma membrane

Molecular Function:integrin binding; kinase binding; protein binding; protein kinase binding

Biological Process: actin filament organization; activation of protein kinase activity; bleb formation; blood vessel endothelial cell migration; cell adhesion; cell death; cell migration; cell proliferation; cell-matrix adhesion; early endosome to late endosome transport; embryo implantation; lipid raft formation; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; regulation of angiogenesis; regulation of glomerular filtration; regulation of kinase activity; T cell mediated cytotoxicity

Disease: Nephrotic Syndrome, Type 10

NCBI Summary:This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]
UniProt Code:P54851
NCBI GenInfo Identifier:1706643
NCBI Gene ID:2013
NCBI Accession:P54851.1
UniProt Secondary Accession:P54851,B2R7V6, D3DUF8,
UniProt Related Accession:P54851
Molecular Weight:19,199 Da
NCBI Full Name:Epithelial membrane protein 2
NCBI Synonym Full Names:epithelial membrane protein 2
NCBI Official Symbol:EMP2  
NCBI Official Synonym Symbols:XMP  
NCBI Protein Information:epithelial membrane protein 2
UniProt Protein Name:Epithelial membrane protein 2
UniProt Synonym Protein Names:Protein XMP
Protein Family:Epithelial membrane protein
UniProt Gene Name:EMP2  
UniProt Entry Name:EMP2_HUMAN
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