Cell Biology Antibodies 13
Anti-EML1 Antibody (CAB17479)
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- SKU:
- CAB17479
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-EML1 Antibody |
| Antibody SKU: | CAB17479 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human EML1 (NP_004425.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human EML1 (NP_004425.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEDG FSSY SSLY DTSS LLQF CNDD SASA ASSM EVTD RIAS LEQR VQMQ EDDI QLLK SALA DVVR RLNI TEEQ QAVL NRKG PTKA RPLM QTLP LRTT VNNG TVLP KKPT GSLP SPSG VRKE TAVP ATKS NIKR TSSS ERVS PGGR RESN GDSR GNRN RTGS |
| Gene ID: | 2009 |
| Uniprot: | O00423 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | BH, ELP79, EMAP, EMAPL, HuEMAP, EML1 |
| Background: | Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | EML1: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Belongs to the WD repeat EMAP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Microtubule-binding Chromosomal Location of Human Ortholog: 14q32 Cellular Component: microtubule; microtubule associated complex; perinuclear region of cytoplasm; cytosol Molecular Function:tubulin binding; protein binding; microtubule binding; calcium ion binding Biological Process: mitotic spindle organization and biogenesis; neuroblast proliferation; hemopoietic progenitor cell differentiation; microtubule cytoskeleton organization and biogenesis; brain development |
| NCBI Summary: | Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00423 |
| NCBI GenInfo Identifier: | 254763417 |
| NCBI Gene ID: | 2009 |
| NCBI Accession: | O00423.3 |
| UniProt Secondary Accession: | O00423,Q86U15, Q8N536, Q8N5C4, Q8WWL6, |
| UniProt Related Accession: | O00423 |
| Molecular Weight: | 91,985 Da |
| NCBI Full Name: | Echinoderm microtubule-associated protein-like 1 |
| NCBI Synonym Full Names: | echinoderm microtubule associated protein like 1 |
| NCBI Official Symbol: | EML1 |
| NCBI Official Synonym Symbols: | EMAP; ELP79; EMAPL; HuEMAP |
| NCBI Protein Information: | echinoderm microtubule-associated protein-like 1; EMAP-1; huEMAP-1 |
| UniProt Protein Name: | Echinoderm microtubule-associated protein-like 1 |
| Protein Family: | Echinoderm microtubule-associated protein |
| UniProt Gene Name: | EML1 |
| UniProt Entry Name: | EMAL1_HUMAN |
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