Cell Biology Antibodies 9
Anti-EMG1 Antibody (CAB4421)
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- SKU:
- CAB4421
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EMG1
- Synonyms:
- C2F
- Synonyms:
- Grcc2f
- Synonyms:
- NEP1
- Research Area:
- Cell Biology
Description
| Product Name: | EMG1 Rabbit pAb |
| Product Code: | CAB4421 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | EMG1, C2F, Grcc2f, NEP1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human EMG1 (NP_006322.4). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, Mouse heart, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human EMG1 (NP_006322.4). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAP SDGF KPRE RSGG EQAQ DWDA LPPK RPRL GAGN KIGG RRLI VVLE GASL ETVK VGKT YELL NCDK HKSI LLKN GRDP GEAR PDIT HQSL LMLM DSPL NRAG LLQV YIHT QKNV LIEV NPQT RIPR TFDR FCGL MVQL LHKL SVRA ADGP QKLL KVIK NPVS DHFP VGCM KVGT SFSI PVVS DVRE LVPS SDPI VFVV GAFA HGKV SVEY TEKM VSIS NYPL SAAL TCAK LTTA FEEV WGVI |
| Gene ID: | 10436 |
| Uniprot: | Q92979 |
| Cellular Location: | Nucleus, nucleolus |
| Calculated MW: | 26kDa |
| Observed MW: | 27kDa |
| UniProt Protein Function: | C2F: Involved in 40S ribosomal subunit biogenesis and 18S rRNA processing. Specifically catalyzes the N1-methylation of pseudouridine at position 1248 (Psi1248) in 18S rRNA. Thus, appears to be the methyltransferase involved in the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) in position 1248 in 18S rRNA. Is not able to methylate uridine at this position. Defects in EMG1 are the cause of Bowen-Conradi syndrome (BWCNS). BWCNS is a combination of malformations characterized in newborns by low birth weight, microcephaly, mild joint restriction, a prominent nose, micrognathia, fifth finger clinodactyly, and 'rocker-bottom' feet. The syndrome is transmitted as an autosomal recessive trait. The prognosis is poor, with all infants dying within the first few months of life. Belongs to the NEP1 family. |
| UniProt Protein Details: | Protein type:EC 2.1.1.-; RNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 12p13.3 Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function:rRNA binding; RNA binding Biological Process: ribosomal small subunit biogenesis and assembly; rRNA methylation; rRNA processing Disease: Bowen-conradi Syndrome |
| NCBI Summary: | This gene encodes an essential, conserved eukaryotic protein involved in ribosome biogenesis. In yeast, the related protein is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome.[provided by RefSeq, May 2010] |
| UniProt Code: | Q92979 |
| NCBI GenInfo Identifier: | 20532172 |
| NCBI Gene ID: | 10436 |
| NCBI Accession: | Q92979.4 |
| UniProt Secondary Accession: | Q92979,O00675, O00726, |
| UniProt Related Accession: | Q92979 |
| Molecular Weight: | 244 |
| NCBI Full Name: | Ribosomal RNA small subunit methyltransferase NEP1 |
| NCBI Synonym Full Names: | EMG1 N1-specific pseudouridine methyltransferase |
| NCBI Official Symbol: | EMG1 |
| NCBI Official Synonym Symbols: | C2F; NEP1; Grcc2f |
| NCBI Protein Information: | ribosomal RNA small subunit methyltransferase NEP1; EMG1 nucleolar protein homolog; essential for mitotic growth 1; ribosome biogenesis protein NEP1; 18S rRNA Psi1248 methyltransferase; 18S rRNA (pseudouridine(1248)-N1)-methyltransferase; 18S rRNA (pseudouridine-N1-)-methyltransferase NEP1 |
| UniProt Protein Name: | Ribosomal RNA small subunit methyltransferase NEP1 |
| UniProt Synonym Protein Names: | 18S rRNA (pseudouridine(1248)-N1)-methyltransferase; 18S rRNA Psi1248 methyltransferase; Nucleolar protein EMG1 homolog; Protein C2f; Ribosome biogenesis protein NEP1 |
| UniProt Gene Name: | EMG1 |
| UniProt Entry Name: | NEP1_HUMAN |
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