Cell Biology Antibodies 17
Anti-Emerin Antibody (CAB4187)
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- SKU:
- CAB4187
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Emerin Antibody |
| Antibody SKU: | CAB4187 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Emerin |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, Mouse brain, Rat lung |
| Immunogen: | A synthesized peptide derived from human Emerin |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2010 |
| Uniprot: | P50402 |
| Cellular Location: | |
| Calculated MW: | 29kDa |
| Observed MW: | 30KDa/35KDa |
| Synonyms: | EDMD, LEMD5, STA |
| Background: | Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | emerin: a single pass membrane protein that spans the inner nuclear membrane. A serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It interacts with lamins A and C, and mediates membrane anchorage to the cytoskeleton. Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through an exportin 1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Colocalized with BAF at the central region of the assembling nuclear rim, near spindle-attachment sites. Hyper-phosphorylated on tyrosine in cells overexpressing HER2. Directly phosphorylated by Src and Abl. Phosphorylated by Src at Y59, Y74 and Y95. May function as a downstream effector and signal integrator for tyrosine kinase signaling pathways at the nuclear envelope. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Cellular Component: microtubule; nuclear outer membrane; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear inner membrane; nuclear envelope Molecular Function:protein binding; beta-tubulin binding; actin binding Biological Process: positive regulation of protein export from nucleus; mitotic nuclear envelope reassembly; muscle development; muscle contraction; negative regulation of fibroblast proliferation; mitotic nuclear envelope disassembly; mitotic cell cycle Disease: Emery-dreifuss Muscular Dystrophy 1, X-linked |
| NCBI Summary: | Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50402 |
| NCBI GenInfo Identifier: | 1706639 |
| NCBI Gene ID: | 2010 |
| NCBI Accession: | P50402.1 |
| UniProt Secondary Accession: | P50402,Q6FI02, |
| UniProt Related Accession: | P50402 |
| Molecular Weight: | |
| NCBI Full Name: | Emerin |
| NCBI Synonym Full Names: | emerin |
| NCBI Official Symbol: | EMD |
| NCBI Official Synonym Symbols: | STA; EDMD; LEMD5 |
| NCBI Protein Information: | emerin; LEM domain containing 5 |
| UniProt Protein Name: | Emerin |
| Protein Family: | Emerin |
| UniProt Gene Name: | EMD |
| UniProt Entry Name: | EMD_HUMAN |
 | Western blot - Emerin Rabbit mAb (CAB4187) |
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