Epigenetics & Nuclear Signaling Antibodies 4

Anti-EME2 Antibody (CAB9891)

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SKU:
CAB9891
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-EME2 Antibody
Antibody SKU:CAB9891
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human EME2 (NP_001244299.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human EME2 (NP_001244299.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MARV GPGR AGVS CQGR GRGR GGSG QRRP PTWE ISDS DAED SAGS EAAA RARD PAGE RRAA AEAL RLLR PEQV LKRL AVCV DTAI LEDA GADV LMEA LEAL GCEC RIEP QRPA RSLR WTRA SPDP CPRS LPPE VWAA GEQE LLLL LEPE EFLQ GVAT LTQI SGPT HWVP WISP ETTA RPHL AVIG LDAY LWSR QHVS RGTQ QPES PKVA GAEV AVSW PEVE
Gene ID:197342
Uniprot:A4GXA9
Cellular Location:Nucleus
Calculated MW:26kDa/41kDa
Observed MW:41kDa
Synonyms:EME2, SLX2B, gs125
Background:
UniProt Protein Function:EME2: Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. Belongs to the EME1/MMS4 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Deoxyribonuclease; EC 3.1.22.-

Chromosomal Location of Human Ortholog: 16p13.3

NCBI Summary:EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
UniProt Code:A4GXA9
NCBI GenInfo Identifier:635377448
NCBI Gene ID:197342
NCBI Accession:A4GXA9.3
UniProt Secondary Accession:A4GXA9,Q8TEP2, Q96RY3,
UniProt Related Accession:A4GXA9
Molecular Weight:26,446 Da
NCBI Full Name:Probable crossover junction endonuclease EME2
NCBI Synonym Full Names:essential meiotic structure-specific endonuclease subunit 2
NCBI Official Symbol:EME2  
NCBI Official Synonym Symbols:SLX2B; gs125  
NCBI Protein Information:probable crossover junction endonuclease EME2
UniProt Protein Name:Probable crossover junction endonuclease EME2
Protein Family:Probable crossover junction endonuclease
UniProt Gene Name:EME2  
UniProt Entry Name:EME2_HUMAN
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