Neuroscience

Anti-ELP3 Antibody (CAB9877)

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SKU:
CAB9877
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Neuroscience

Description

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Antibody Name:Anti-ELP3 Antibody
Antibody SKU:CAB9877
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 358-547 of human ELP3 (NP_060561.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 358-547 of human ELP3 (NP_060561.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PWTR VYRV QRDI PMPL VSSG VEHG NLRE LALA RMKD LGIQ CRDV RTRE VGIQ EIHH KVRP YQVE LVRR DYVA NGGW ETFL SYED PDQD ILIG LLRL RKCS EETF RFEL GGGV SIVR ELHV YGSV VPVS SRDP TKFQ HQGF GMLL MEEA ERIA REEH GSGK IAVI SGVG TRNY YRKI GYRL QGPY MVKM LK
Gene ID:55140
Uniprot:Q9H9T3
Cellular Location:Cytoplasm, Nucleus
Calculated MW:49kDa/52kDa/60kDa/62kDa
Observed MW:62kDa
Synonyms:ELP3, KAT9
Background:
UniProt Protein Function:ELP3: a histone acetyltransferase. A subunit of the Elongator complex, which associates with the elongating, hyperphosphorylated form of RNA polymerase II.
UniProt Protein Details:

Protein type:EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: cytoplasm; Elongator holoenzyme complex; histone acetyltransferase complex; nucleolus; transcription elongation factor complex

Molecular Function:H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; phosphorylase kinase regulator activity; protein binding

Biological Process: central nervous system development; neuron migration; positive regulation of cell migration; regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; tRNA wobble uridine modification

NCBI Summary:ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]
UniProt Code:Q9H9T3
NCBI GenInfo Identifier:145558902
NCBI Gene ID:55140
NCBI Accession:Q9H9T3.2
UniProt Secondary Accession:Q9H9T3,Q53G84, Q6AWB0, Q9BVF7, Q9NVZ1, B4DE19, B4DIG1 E2QRI5,
UniProt Related Accession:Q9H9T3
Molecular Weight:52,202 Da
NCBI Full Name:Elongator complex protein 3
NCBI Synonym Full Names:elongator acetyltransferase complex subunit 3
NCBI Official Symbol:ELP3  
NCBI Official Synonym Symbols:KAT9  
NCBI Protein Information:elongator complex protein 3
UniProt Protein Name:Elongator complex protein 3
Protein Family:Elongator complex protein
UniProt Gene Name:ELP3  
UniProt Entry Name:ELP3_HUMAN
Anti-ELP3 Polyclonal Antibody (CAB9877)Western blot analysis of extracts of Mouse kidney, using ELP3 antibody (CAB9877) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s.
Anti-ELP3 Polyclonal Antibody (CAB9877)Immunohistochemistry of paraffin-embedded rat cerebellum using ELP3 antibody (CAB9877) at dilution of 1:100 (40x lens).
Anti-ELP3 Polyclonal Antibody (CAB9877)Immunohistochemistry of paraffin-embedded mouse cerebellum using ELP3 antibody (CAB9877) at dilution of 1:100 (40x lens).
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