Epigenetics & Nuclear Signaling Antibodies 4
Anti-Elongin-A2 Antibody (CAB8492)
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- SKU:
- CAB8492
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Elongin-A2 Antibody |
| Antibody SKU: | CAB8492 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 534-753 of human TCEB3B (NP_057511.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse heart, Mouse brain, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 534-753 of human TCEB3B (NP_057511.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AQVL RNNP DALS DVGE VPYW VLEP VLEG WRPD QLYR RKKD NHAL VRET DELR RNHC FQDF KEEK PQEN KTWR EQYL RLPD APEQ RLRV MTTN IRSA RGNN PNGR EAKM ICFK SVAK TPYD TSRR QEKS AGDA DPEN GEIK PASK PAGS SHTP SSQS SSGG GRDS SSSI LRWL PEKR ANPC LSSS NEHA APAA KTRK QAAK KVAP LMAK AIRD YKRR FSRR |
| Gene ID: | 51224 |
| Uniprot: | Q8IYF1 |
| Cellular Location: | Nucleus |
| Calculated MW: | 83kDa |
| Observed MW: | 100kDa |
| Synonyms: | ELOA2, HsT832, TCEB3B, TCEB3L |
| Background: | This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. |
| UniProt Protein Function: | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). |
| NCBI Summary: | This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IYF1 |
| NCBI GenInfo Identifier: | 45439357 |
| NCBI Gene ID: | 51224 |
| NCBI Accession: | NP_057511.2 |
| UniProt Secondary Accession: | Q8IYF1,Q9P2V9, |
| UniProt Related Accession: | Q8IYF1 |
| Molecular Weight: | 83 kDa |
| NCBI Full Name: | elongin-A2 |
| NCBI Synonym Full Names: | elongin A2 |
| NCBI Official Symbol: | ELOA2 |
| NCBI Official Synonym Symbols: | HsT832; TCEB3B; TCEB3L |
| NCBI Protein Information: | elongin-A2 |
| UniProt Protein Name: | Elongin-A2 |
| UniProt Synonym Protein Names: | RNA polymerase II transcription factor SIII subunit A2; Transcription elongation factor B polypeptide 3B |
| UniProt Gene Name: | ELOA2 |
 | Western blot analysis of extracts of various cell lines, using TCEB3B antibody (CAB8492) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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