Cell Death Antibodies 1

Anti-ELMO2 Antibody (CAB13785)

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SKU:
CAB13785
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-ELMO2 Antibody
Antibody SKU:CAB13785
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 42-120 of human ELMO2 (NP_877496.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 42-120 of human ELMO2 (NP_877496.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SLPN PEYY TLRY ADGP QLYI TEQT RSDI KNGT ILQL AISP SRAA RQLM ERTQ SSNM ETRL DAMK ELAK LSAD VTFA TEF
Gene ID:63916
Uniprot:Q96JJ3
Cellular Location:Cytoplasm, Membrane, cytosol
Calculated MW:72kDa/82kDa
Observed MW:83kDa
Synonyms:ELMO2, CED-12, CED12, Ced-12A, ELMO-2, VMPI
Background:The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ELMO2: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: cytoplasm; cytosol; membrane

Molecular Function:protein binding; receptor tyrosine kinase binding

Biological Process: vascular endothelial growth factor receptor signaling pathway

NCBI Summary:The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Code:Q96JJ3
NCBI GenInfo Identifier:30913107
NCBI Gene ID:63916
NCBI Accession:Q96JJ3.2
UniProt Secondary Accession:Q96JJ3,Q5JVZ6, Q7Z5G9, Q96CJ2, Q96ME5, Q96PA9, Q9H938 Q9H9L5, Q9HAH0, Q9NQQ6, E1P5T3,
UniProt Related Accession:Q96JJ3
Molecular Weight:72,798 Da
NCBI Full Name:Engulfment and cell motility protein 2
NCBI Synonym Full Names:engulfment and cell motility 2
NCBI Official Symbol:ELMO2  
NCBI Official Synonym Symbols:CED12; CED-12; ELMO-2; Ced-12A  
NCBI Protein Information:engulfment and cell motility protein 2
UniProt Protein Name:Engulfment and cell motility protein 2
UniProt Synonym Protein Names:Protein ced-12 homolog A; hCed-12A
Protein Family:Engulfment and cell motility protein
UniProt Gene Name:ELMO2  
UniProt Entry Name:ELMO2_HUMAN
Anti-ELMO2 Antibody (CAB13785)Western blot analysis of extracts of various cell lines, using ELMO2 antibody (CAB13785) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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