Epigenetics & Nuclear Signaling Antibodies 2
Anti-ELL Antibody (CAB16449)
- SKU:
- CAB16449
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ELL Antibody |
| Antibody SKU: | CAB16449 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ELL (NP_006523.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, 293T, mouse testis, mouse liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ELL (NP_006523.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PAVN GKLG VPNG REAL LPTP GPPA STDT LSSS THLP PRLE PPRA HDPL ADVS NDLG HSGR DCEH GEAA APAP TVRL GLPL LTDC AQPS RPHG SPSR SKPK K |
| Gene ID: | 8178 |
| Uniprot: | P55199 |
| Cellular Location: | Cajal body, Nucleus, Nucleus speckle |
| Calculated MW: | 68kDa |
| Observed MW: | 68kDa |
| Synonyms: | ELL, C19orf17, ELL1, MEN, PPP1R68 |
| Background: |
| UniProt Protein Function: | ELL: Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein. Belongs to the ELL/occludin family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription initiation complex; Oncoprotein Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: nucleoplasm; Cajal body; transcription elongation factor complex; nuclear speck Molecular Function:protein binding; phosphatase binding Biological Process: transcription from RNA polymerase II promoter; viral reproduction; in utero embryonic development; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of viral transcription; positive regulation of RNA elongation; RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; snRNA transcription from RNA polymerase II promoter; gene expression; snRNA transcription from RNA polymerase III promoter |
| UniProt Code: | P55199 |
| NCBI GenInfo Identifier: | 1706635 |
| NCBI Gene ID: | 8178 |
| NCBI Accession: | P55199.1 |
| UniProt Related Accession: | P55199 |
| Molecular Weight: | 621 |
| NCBI Full Name: | RNA polymerase II elongation factor ELL |
| NCBI Synonym Full Names: | elongation factor RNA polymerase II |
| NCBI Official Symbol: | ELL |
| NCBI Official Synonym Symbols: | MEN; ELL1; PPP1R68; C19orf17 |
| NCBI Protein Information: | RNA polymerase II elongation factor ELL; ELL gene (11-19 lysine-rich leukemia gene); eleven-nineteen lysine-rich leukemia protein; protein phosphatase 1, regulatory subunit 68 |
| UniProt Protein Name: | RNA polymerase II elongation factor ELL |
| UniProt Synonym Protein Names: | Eleven-nineteen lysine-rich leukemia protein |
| Protein Family: | ELL-associated factor |
| UniProt Gene Name: | ELL |
| UniProt Entry Name: | ELL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ELL antibody (CAB16449) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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