Cell Biology Antibodies 18
Anti-ELK4 Antibody (CAB18360)
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- SKU:
- CAB18360
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ELK4 Antibody |
| Antibody SKU: | CAB18360 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human ELK4. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human ELK4. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2005 |
| Uniprot: | P28324 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | SAP1, ELK4 |
| Background: |
| UniProt Protein Function: | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. |
| NCBI Summary: | This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28324 |
| NCBI GenInfo Identifier: | 11496882 |
| NCBI Gene ID: | 2005 |
| NCBI Accession: | NP_068567 |
| UniProt Related Accession: | P28324 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | ETS domain-containing protein Elk-4 isoform b |
| NCBI Synonym Full Names: | ETS transcription factor ELK4 |
| NCBI Official Symbol: | ELK4 |
| NCBI Official Synonym Symbols: | SAP1 |
| NCBI Protein Information: | ETS domain-containing protein Elk-4 |
| UniProt Protein Name: | ETS domain-containing protein Elk-4 |
| UniProt Synonym Protein Names: | Serum response factor accessory protein 1; SAP-1; SRF accessory protein 1 |
| Protein Family: | ETS domain-containing protein |
| UniProt Gene Name: | ELK4 |
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