Epigenetics & Nuclear Signaling Antibodies 1
Anti-ELK1 Antibody (CAB0789)
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- SKU:
- CAB0789
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ELK1 Antibody |
| Antibody SKU: | CAB0789 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-250 of human ELK1 (NP_005220.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Jurkat, HT-29, K-562, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-250 of human ELK1 (NP_005220.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EVAG CSTE DCPP QPEV SVTS TMPN VAPA AIHA APGD TVSG KPGT PKGA GMAG PGGL ARSS RNEY MRSG LYST FTIQ SLQP QPPP HPRP AVVL PSAA PAGA AAPP SGSR STSP SPLE ACLE AEEA GLPL QVIL TPPE APNL KSEE LNVE PGLG RALP PEVK V |
| Gene ID: | 2002 |
| Uniprot: | P19419 |
| Cellular Location: | Nucleus |
| Calculated MW: | 11kDa/44kDa |
| Observed MW: | 60kDa |
| Synonyms: | ELK1 |
| Background: | This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. |
| UniProt Protein Function: | ELK1: a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: Xp11.2 Cellular Component: cell soma; dendrite; mitochondrion; nerve terminal; nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding; transcription factor activity Biological Process: cell differentiation; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to light stimulus; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P19419 |
| NCBI GenInfo Identifier: | 12643407 |
| NCBI Gene ID: | 2002 |
| NCBI Accession: | P19419.2 |
| UniProt Secondary Accession: | P19419,O75606, O95058, Q969X8, Q9UJM4, B2R7H4, |
| UniProt Related Accession: | P19419 |
| Molecular Weight: | |
| NCBI Full Name: | ETS domain-containing protein Elk-1 |
| NCBI Synonym Full Names: | ELK1, ETS transcription factor |
| NCBI Official Symbol: | ELK1 |
| NCBI Protein Information: | ETS domain-containing protein Elk-1 |
| UniProt Protein Name: | ETS domain-containing protein Elk-1 |
| Protein Family: | ETS domain-containing protein |
| UniProt Gene Name: | ELK1 |
| UniProt Entry Name: | ELK1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ELK1 antibody (CAB0789) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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