Epigenetics & Nuclear Signaling Antibodies 4
Anti-ELF4 Antibody (CAB7180)
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- SKU:
- CAB7180
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ELF4 Antibody |
| Antibody SKU: | CAB7180 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ELF4 (NP_001412.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ELF4 (NP_001412.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAIT LQPS DLIF EFAS NGMD DDIH QLED PSVF PAVI VEQV PYPD LLHL YSGL ELDD VHNG IITD GTLC MTQD QILE GSFL LTDD NEAT SHTM STAE VLLN MESP SDIL DEKQ IFST SEML PDSD PAPA VTLP NYLF PASE PDAL NRAG DTSD QEGH SLEE KASR EESA KKTG KSKK RIRK TKGN RSTS PVTD PSIP IRKK |
| Gene ID: | 2000 |
| Uniprot: | Q99607 |
| Cellular Location: | Nucleus, PML body |
| Calculated MW: | 70kDa |
| Observed MW: |
| Synonyms: | ELF4, ELFR, MEF |
| Background: | The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | ELF4: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG. Belongs to the ETS family. |
| UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: Xq26 Cellular Component: Golgi apparatus; nuclear membrane; nucleoplasm; PML body Molecular Function:protein binding Biological Process: cell differentiation; natural killer cell proliferation; NK T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010] |
| UniProt Code: | Q99607 |
| NCBI GenInfo Identifier: | 68052244 |
| NCBI Gene ID: | 2000 |
| NCBI Accession: | Q99607.1 |
| UniProt Secondary Accession: | Q99607,O60435, D3DTG1, |
| UniProt Related Accession: | Q99607 |
| Molecular Weight: | 70,730 Da |
| NCBI Full Name: | ETS-related transcription factor Elf-4 |
| NCBI Synonym Full Names: | E74 like ETS transcription factor 4 |
| NCBI Official Symbol: | ELF4 |
| NCBI Official Synonym Symbols: | MEF; ELFR |
| NCBI Protein Information: | ETS-related transcription factor Elf-4 |
| UniProt Protein Name: | ETS-related transcription factor Elf-4 |
| UniProt Synonym Protein Names: | E74-like factor 4; Myeloid Elf-1-like factor |
| Protein Family: | ETS-related transcription factor |
| UniProt Gene Name: | ELF4 |
| UniProt Entry Name: | ELF4_HUMAN |
 | Immunofluorescence analysis of A549 cells using ELF4 antibody (CAB7180). Blue: DAPI for nuclear staining. |
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