ChIP Antibodies

Anti-ELAC2 Antibody (CAB7128)

(No reviews yet) Write a Review
SKU:
CAB7128
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ELAC2 Antibody
Antibody SKU:CAB7128
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, NCI-H460
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MWAL CSLL RSAA GRTM SQGR TISQ APAR RERP RKDP LRHL RTRE KRGP SGCS GGPN TVYL QVVA AGSR DSGA ALYV FSEF NRYL FNCG EGVQ RLMQ EHKL KVAR LDNI FLTR MHWS NVGG LSGM ILTL KETG LPKC VLSG PPQL EKYL EAIK IFSG PLKG IELA VRPH SAPE YEDE TMTV YQIP IHSE QRRG KHQP WQSP ERPL SRLS PERS SDSE SNEN EPHL PHGV SQRR GVRD SSLV VAFI CKLH LKRG NFLV LKAK EMGL PVGT AA
Gene ID:60528
Uniprot:Q9BQ52
Cellular Location:Mitochondrion, Nucleus
Calculated MW:50kDa/56kDa/87kDa/92kDa
Observed MW:105kDa
Synonyms:ELAC2, COXPD17, ELC2, HPC2
Background:The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ELAC2: a zinc phosphodiesterase. Putative prostate cancer susceptibility protein.
UniProt Protein Details:

Protein type:Ribonuclease; Oncoprotein; RNA processing; EC 3.1.26.11; Phosphodiesterase

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; mitochondrion; nucleus

Molecular Function:metal ion binding; endonuclease activity

Disease: Prostate Cancer, Hereditary, 2; Combined Oxidative Phosphorylation Deficiency 17

NCBI Summary:The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Code:Q9BQ52
NCBI GenInfo Identifier:41017788
NCBI Gene ID:60528
NCBI Accession:Q9BQ52.2
UniProt Secondary Accession:Q9BQ52,Q6IA94, Q9HAS8, Q9HAS9, Q9NVT1, B4DPL9,
UniProt Related Accession:Q9BQ52
Molecular Weight:826
NCBI Full Name:Zinc phosphodiesterase ELAC protein 2
NCBI Synonym Full Names:elaC ribonuclease Z 2
NCBI Official Symbol:ELAC2  
NCBI Official Synonym Symbols:ELC2; HPC2; COXPD17  
NCBI Protein Information:zinc phosphodiesterase ELAC protein 2; RNase Z 2; tRNase Z 2; elaC homolog 2; ribonuclease Z 2; tRNase Z (long form); tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2
UniProt Protein Name:Zinc phosphodiesterase ELAC protein 2
UniProt Synonym Protein Names:ElaC homolog protein 2; Heredity prostate cancer protein 2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z 2
Protein Family:Zinc phosphodiesterase ELAC protein
UniProt Gene Name:ELAC2  
UniProt Entry Name:RNZ2_HUMAN
Anti-ELAC2 Antibody (CAB7128)Western blot analysis of extracts of various cell lines, using ELAC2 Antibody (CAB7128) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-ELAC2 Antibody (CAB7128)Immunohistochemistry of paraffin-embedded rat testis using ELAC2 antibody (CAB7128) at dilution of 1:200 (40x lens).
Anti-ELAC2 Antibody (CAB7128)Immunohistochemistry of paraffin-embedded human colon carcinoma using ELAC2 antibody (CAB7128) at dilution of 1:200 (40x lens).
Anti-ELAC2 Antibody (CAB7128)Immunohistochemistry of paraffin-embedded mouse kidney using ELAC2 antibody (CAB7128) at dilution of 1:200 (40x lens).
Anti-ELAC2 Antibody (CAB7128)Immunofluorescence analysis of MCF7 cells using ELAC2 antibody (CAB7128). Blue: DAPI for nuclear staining.
View AllClose

0 Reviews

View AllClose

Related Products