Metabolism Antibodies 2
Anti-EIF5B Antibody (CAB5888)
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- SKU:
- CAB5888
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-EIF5B Antibody |
| Antibody SKU: | CAB5888 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 901-1220 of human EIF5B (NP_056988.3). |
| Application: | IF |
| Recommended Dilution: | IF 1:10 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 901-1220 of human EIF5B (NP_056988.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IRGL LLPP PMKE LRVK NQYE KHKE VEAA QGVK ILGK DLEK TLAG LPLL VAYK EDEI PVLK DELI HELK QTLN AIKL EEKG VYVQ ASTL GSLE ALLE FLKT SEVP YAGI NIGP VHKK DVMK ASVM LEHD PQYA VILA FDVR IERD AQEM ADSL GVRI FSAE IIYH LFDA FTKY RQDY KKQK QEEF KHIA VFPC KIKI LPQY IFNS RDPI VMGV TVEA GQVK QGTP MCVP SKNF VDIG IVTS IEIN HKQV DVAK KGQE VCVK IEPI PGES PKMF GRHF EATD ILVS KISR QSID ALKD WFRD EMQK SDWQ LIVE LKKV FEII |
| Gene ID: | 9669 |
| Uniprot: | O60841 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 138kDa |
| Observed MW: |
| Synonyms: | EIF5B, IF2 |
| Background: | Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. |
| UniProt Protein Function: | EIF5B: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. Belongs to the IF-2 family. |
| UniProt Protein Details: | Protein type:Translation initiation; Translation Chromosomal Location of Human Ortholog: 2q11.2 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:GTPase activity; protein binding; GTP binding; translation initiation factor activity Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression; regulation of translational initiation |
| NCBI Summary: | Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60841 |
| NCBI GenInfo Identifier: | 269849752 |
| NCBI Gene ID: | 9669 |
| NCBI Accession: | O60841.4 |
| UniProt Secondary Accession: | O60841,O95805, Q53RV7, Q53SI8, Q9UF81, Q9UMN7, |
| UniProt Related Accession: | O60841 |
| Molecular Weight: | 1220 |
| NCBI Full Name: | Eukaryotic translation initiation factor 5B |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 5B |
| NCBI Official Symbol: | EIF5B |
| NCBI Official Synonym Symbols: | IF2 |
| NCBI Protein Information: | eukaryotic translation initiation factor 5B; eIF-5B; translation initiation factor IF2; translation initiation factor IF-2 |
| UniProt Protein Name: | Eukaryotic translation initiation factor 5B |
| UniProt Synonym Protein Names: | Translation initiation factor IF-2 |
| Protein Family: | Eukaryotic translation initiation factor |
| UniProt Gene Name: | EIF5B |
| UniProt Entry Name: | IF2P_HUMAN |
 | Immunofluorescence analysis of A549 cells using EIF5B antibody (CAB5888). Blue: DAPI for nuclear staining. |
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