Signal Transduction Antibodies 1

Anti-EIF4EBP2 Antibody (CAB13691)

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SKU:
CAB13691
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-EIF4EBP2 Antibody
Antibody SKU:CAB13691
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 61-120 of human EIF4EBP2 (NP_004087.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 61-120 of human EIF4EBP2 (NP_004087.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DRRN SPMA QTPP CHLP NIPG VTSP GTLI EDSK VEVN NLNN LNNH DRKH AVGD DAQF EMDI
Gene ID:1979
Uniprot:Q13542
Cellular Location:
Calculated MW:12kDa
Observed MW:16kDa
Synonyms:EIF4EBP2, 4EBP2, PHASII
Background:This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.
UniProt Protein Function:4E-BP2: eukaryotic translation initiation factor 4E binding protein 2
UniProt Protein Details:

Protein type:Translation; Translation initiation

Chromosomal Location of Human Ortholog: 10q21-q22

Cellular Component: cytoplasm

Molecular Function:eukaryotic initiation factor 4E binding; protein binding; translation repressor activity

Biological Process: cAMP-mediated signaling; insulin receptor signaling pathway; memory; negative regulation of translational initiation; regulation of synaptic plasticity; regulation of synaptic transmission; social behavior; TOR signaling pathway; translation

NCBI Summary:This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
UniProt Code:Q13542
NCBI GenInfo Identifier:34921510
NCBI Gene ID:1979
NCBI Accession:Q13542.1
UniProt Related Accession:Q13542
Molecular Weight:12,939 Da
NCBI Full Name:Eukaryotic translation initiation factor 4E-binding protein 2
NCBI Synonym Full Names:eukaryotic translation initiation factor 4E binding protein 2
NCBI Official Symbol:EIF4EBP2  
NCBI Official Synonym Symbols:4EBP2; PHASII  
NCBI Protein Information:eukaryotic translation initiation factor 4E-binding protein 2
UniProt Protein Name:Eukaryotic translation initiation factor 4E-binding protein 2
UniProt Gene Name:EIF4EBP2  
UniProt Entry Name:4EBP2_HUMAN
Anti-EIF4EBP2 Antibody (CAB13691)Western blot analysis of extracts of various cell lines, using EIF4EBP2 antibody (CAB13691) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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system_update_altDatasheetHuman EIF4EBP2 Recombinant Protein Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4