Immunology Antibodies 2
Anti-EIF3M Antibody (CAB4426)
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- SKU:
- CAB4426
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EIF3M
- Synonyms:
- B5
- Synonyms:
- GA17
- Synonyms:
- PCID1
- Synonyms:
- TANGO7
- Synonyms:
- hfl-B5
- Research Area:
- Immunology
Description
| Product Name: | EIF3M Rabbit pAb |
| Product Code: | CAB4426 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | EIF3M, B5, GA17, PCID1, TANGO7, hfl-B5 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-374 of human EIF3M (NP_006351.2). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, A-549, HepG2, NCI-H460, Mouse spleen, Mouse heart, Mouse thymus, Rat spleen, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-374 of human EIF3M (NP_006351.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSVP AFID ISEE DQAA ELRA YLKS KGAE ISEE NSEG GLHV DLAQ IIEA CDVC LKED DKDV ESVM NSVV SLLL ILEP DKQE ALIE SLCE KLVK FREG ERPS LRLQ LLSN LFHG MDKN TPVR YTVY CSLI KVAA SCGA IQYI PTEL DQVR KWIS DWNL TTEK KHTL LRLL YEAL VDCK KSDA ASKV MVEL LGSY TEDN ASQA RVDA HRCI VRAL KDPN AFLF DHLL TLKP VKFL EGEL IHDL LTIF VSAK LASY VKFY QNNK DFID SLGL LHEQ NMAK MRLL TFMG MAVE NKEI SFDT MQQE LQIG ADDV EAFV IDAV RTKM VYCK IDQT QRKV VVSH STHR TFGK QQWQ QLYD TLNA WKQN LNKV KNSL LSLS DT |
| Gene ID: | 10480 |
| Uniprot: | Q7L2H7 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 27kDa/42kDa |
| Observed MW: | 40kDa |
| UniProt Protein Function: | EIF3M: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). Belongs to the eIF-3 subunit M family. |
| UniProt Protein Details: | Protein type:Translation initiation Chromosomal Location of Human Ortholog: 11p13 Cellular Component: eukaryotic translation initiation factor 3 complex Molecular Function:protein binding; translation initiation factor binding; translation initiation factor activity Biological Process: translational initiation; formation of translation preinitiation complex; regulation of translational initiation |
| NCBI Summary: | This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q7L2H7 |
| NCBI GenInfo Identifier: | 74754296 |
| NCBI Gene ID: | 10480 |
| NCBI Accession: | Q7L2H7.1 |
| UniProt Related Accession: | Q7L2H7 |
| Molecular Weight: | Observed: 43 kDaPredicted: 43 kDa |
| NCBI Full Name: | Eukaryotic translation initiation factor 3 subunit M |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 3 subunit M |
| NCBI Official Symbol: | EIF3M |
| NCBI Official Synonym Symbols: | B5; GA17; PCID1; TANGO7; hfl-B5 |
| NCBI Protein Information: | eukaryotic translation initiation factor 3 subunit M |
| UniProt Protein Name: | Eukaryotic translation initiation factor 3 subunit M |
| UniProt Synonym Protein Names: | Fetal lung protein B5; hFL-B5; PCI domain-containing protein 1 |
| UniProt Gene Name: | EIF3M |
| UniProt Entry Name: | EIF3M_HUMAN |
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