Metabolism Antibodies 3
Anti-EIF3L Antibody (CAB9972)
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- SKU:
- CAB9972
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-EIF3L Antibody |
| Antibody SKU: | CAB9972 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human EIF3L (NP_057175.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:4000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HT-1080, NIH/3T3, Mouse heart, Mouse pancreas, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human EIF3L (NP_057175.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSYP ADDY ESEA AYDP YAYP SDYD MHTG DPKQ DLAY ERQY EQQT YQVI PEVI KNFI QYFH KTVS DLID QKVY ELQA SRVS SDVI DQKV YEIQ DIYE NSWT KLTE RFFK NTPW PEAE AIAP QVGN DAVF LILY KELY YRHI YAKV SGGP SLEQ RFES YYNY CNLF NYIL NADG PAPL ELPN QWLW DIID EFIY QFQS FSQY RCKT AKKS EEEI DFLR SNPK IWNV HSVL NV |
| Gene ID: | 51386 |
| Uniprot: | Q9Y262 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 61kDa/66kDa |
| Observed MW: | 67kDa |
| Synonyms: | EIF3L, EIF3EIP, EIF3S11, EIF3S6IP, HSPC021, HSPC025, MSTP005 |
| Background: |
| UniProt Protein Function: | eIF3S6IP: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Belongs to the eIF-3 subunit L family. |
| UniProt Protein Details: | Protein type:RNA-binding; Translation; Translation initiation Chromosomal Location of Human Ortholog: 22q Cellular Component: cytosol; eukaryotic translation initiation factor 3 complex; fibrillar center; membrane; nucleoplasm Molecular Function:protein binding; translation initiation factor activity Biological Process: cellular protein metabolic process; formation of translation preinitiation complex; gene expression; regulation of translational initiation; translation; translational initiation |
| UniProt Code: | Q9Y262 |
| NCBI GenInfo Identifier: | 339275831 |
| NCBI Gene ID: | 51386 |
| NCBI Accession: | NP_001229852.1 |
| UniProt Secondary Accession: | Q9Y262,Q53HQ1, Q53HT4, Q5QTR1, Q5TI15, Q6ICD2, B2RDG6 B4DYB2, G8JLH4, |
| UniProt Related Accession: | Q9Y262 |
| Molecular Weight: | Calculated MW: 61kDa/66kDaObserved MW: 67kDa |
| NCBI Full Name: | eukaryotic translation initiation factor 3 subunit L isoform 2 |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 3 subunit L |
| NCBI Official Symbol: | EIF3L |
| NCBI Official Synonym Symbols: | EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP |
| NCBI Protein Information: | eukaryotic translation initiation factor 3 subunit L |
| UniProt Protein Name: | Eukaryotic translation initiation factor 3 subunit L |
| UniProt Synonym Protein Names: | Eukaryotic translation initiation factor 3 subunit 6-interacting protein |
| UniProt Gene Name: | EIF3L |
| UniProt Entry Name: | EIF3L_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EIF3L antibody (CAB9972) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using EIF3L antibody (CAB9972) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human mammary cancer using EIF3L antibody (CAB9972) at dilution of 1:100 (40x lens). |
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