Name: Anti-EIF2S2 Antibody (CAB17040)
Brand: Metabolism Antibodies 3
SKU: CAB17040
Availability: OutOfStock

Antibody Name:	Anti-EIF2S2 Antibody
Antibody SKU:	CAB17040
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human EIF2S2 (NP_003899.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, LO2, A-549, Rat liver, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human EIF2S2 (NP_003899.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSGD EMIF DPTM SKKK KKKK KPFM LDEE GDTQ TEET QPSE TKEV EPEP TEDK DLEA DEED TRKK DASD DLDD LNFF NQKK KKKK TKKI FDID EAEE GVKD LKIE SDVQ EPTE PEDD LDIM LGNK KKKK KNVK FPDE DEIL EKDE ALED EDNK KDDG ISFS NQTG PAWA GSER DYT
Gene ID:	8894
Uniprot:	P20042
Cellular Location:
Calculated MW:	38kDa
Observed MW:	38kDa

Western blot - EIF2S2 Rabbit pAb (CAB17040)

Synonyms:

EIF2S2, EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta

Background:

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	eIF2-beta: a translational regulatory protein that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
UniProt Protein Details:	Protein type:Translation; Translation initiation Chromosomal Location of Human Ortholog: 20q11.2 Cellular Component: cytoplasm; nucleus; cytosol; eukaryotic translation initiation factor 2 complex Molecular Function:protein binding; RNA binding; translation factor activity, nucleic acid binding; metal ion binding; translation initiation factor activity Biological Process: cellular protein metabolic process; translation; in utero embryonic development; male gonad development; translational initiation; gene expression
NCBI Summary:	Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. [provided by RefSeq, Jul 2008]
UniProt Code:	P20042
NCBI GenInfo Identifier:	12644154
NCBI Gene ID:	8894
NCBI Accession:	P20042.2
UniProt Secondary Accession:	P20042,Q9BVU0, Q9UJE4,
UniProt Related Accession:	P20042
Molecular Weight:	333
NCBI Full Name:	Eukaryotic translation initiation factor 2 subunit 2
NCBI Synonym Full Names:	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
NCBI Official Symbol:	EIF2S2
NCBI Official Synonym Symbols:	EIF2; EIF2B; PPP1R67; EIF2beta; eIF-2-beta
NCBI Protein Information:	eukaryotic translation initiation factor 2 subunit 2; protein phosphatase 1, regulatory subunit 67; eukaryotic translation initiation factor 2 subunit beta
UniProt Protein Name:	Eukaryotic translation initiation factor 2 subunit 2
UniProt Synonym Protein Names:	Eukaryotic translation initiation factor 2 subunit beta; eIF-2-beta
Protein Family:	Eukaryotic translation initiation factor
UniProt Gene Name:	EIF2S2
UniProt Entry Name:	IF2B_HUMAN