Metabolism Antibodies 3
Anti-EIF2AK3 Antibody (CAB18196)
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- SKU:
- CAB18196
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-EIF2AK3 Antibody |
| Antibody SKU: | CAB18196 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human EIF2AK3 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant protein of human EIF2AK3 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9451 |
| Uniprot: | Q9NZJ5 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
| Calculated MW: | 125kDa |
| Observed MW: | 160kDa |
 | Western blot analysis of extracts of HeLa cells, using EIF2AK3 antibody (CAB18196) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunofluorescence analysis of C6 cells using EIF2AK3 Rabbit pAb (CAB18196) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using EIF2AK3 Rabbit pAb (CAB18196) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
| Synonyms: | EIF2AK3, PEK, PERK, WRS |
| Background: | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. |
| NCBI Summary: | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9NZJ5 |
| NCBI GenInfo Identifier: | 296439367 |
| NCBI Gene ID: | 9451 |
| NCBI Accession: | |
| UniProt Related Accession: | Q9NZJ5 |
| Molecular Weight: | 170 |
| NCBI Full Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 2 alpha kinase 3 |
| NCBI Official Symbol: | EIF2AK3 |
| NCBI Official Synonym Symbols: | PEK; WRS; PERK |
| NCBI Protein Information: | eukaryotic translation initiation factor 2-alpha kinase 3 |
| UniProt Protein Name: | |
| UniProt Gene Name: |
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