Anti-EI24 Antibody (CAB19437)
- SKU:
- CAB19437
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EI24
- Synonyms:
- EPG4
- Synonyms:
- PIG8
- Synonyms:
- TP53I8
Description
| Product Name: | EI24 Rabbit pAb |
| Product Code: | CAB19437 |
| Size: | 50uL |
| Synonyms: | EI24, EPG4, PIG8, TP53I8 |
| Applications: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human EI24 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:200 - 1:500 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver, Mouse pancreas |
| Immunogen: | A synthetic peptide of human EI24 |
| Purification Method: | Affinity purification |
| Storage: | Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9538 |
| Uniprot: | O14681 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum membrane, Multi-pass membrane protein, Nucleus membrane |
| Calculated MW: | 37kDa/38kDa |
| Observed MW: | 33kDa |
| UniProt Protein Function: | EI24: a p53-induced gene that appears to play a role in p53-mediated events. May activate apoptosis and reduce tumor invasiveness. Mutations in its gene have been associated with breast cancer. |
| UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q24 Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; nuclear membrane; membrane; endoplasmic reticulum; cytoplasm; integral to membrane Biological Process: response to drug; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; autophagy; negative regulation of cell growth; neuromuscular process controlling balance |
| NCBI Summary: | This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014] |
| UniProt Code: | O14681 |
| NCBI GenInfo Identifier: | 229463041 |
| NCBI Gene ID: | 9538 |
| NCBI Accession: | O14681.4 |
| UniProt Secondary Accession: | O14681,Q9BUQ1, A8K7D6, B4DKL6, |
| UniProt Related Accession: | O14681 |
| Molecular Weight: | 340 |
| NCBI Full Name: | Etoposide-induced protein 2.4 homolog |
| NCBI Synonym Full Names: | etoposide induced 2.4 |
| NCBI Official Symbol: | EI24 |
| NCBI Official Synonym Symbols: | EPG4; PIG8; TP53I8 |
| NCBI Protein Information: | etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; tumor protein p53 inducible protein 8; ectopic P-granules autophagy protein 4 homolog |
| UniProt Protein Name: | Etoposide-induced protein 2.4 homolog |
| UniProt Synonym Protein Names: | p53-induced gene 8 protein |
| Protein Family: | Etoposide-induced protein |
| UniProt Gene Name: | EI24 |
| UniProt Entry Name: | EI24_HUMAN |
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