Metabolism Antibodies 2
Anti-EHHADH Antibody (CAB5717)
- SKU:
- CAB5717
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Antibody Name: | Anti-EHHADH Antibody |
Antibody SKU: | CAB5717 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 444-723 of human EHHADH (NP_001957.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | SW480, A-549, HeLa, HepG2, Mouse small intestine, Rat liver, Rat kidney |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 444-723 of human EHHADH (NP_001957.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | EVIP SQYS SPTT IATV MNLS KKIK KIGV VVGN CFGF VGNR MLNP YYNQ AYFL LEEG SKPE EVDQ VLEE FGFK MGPF RVSD LAGL DVGW KSRK GQGL TGPT LLPG TPAR KRGN RRYC PIPD VLCE LGRF GQKT GKGW YQYD KPLG RIHK PDPW LSKF LSRY RKTH HIEP RTIS QDEI LERC LYSL INEA FRIL GEGI AASP EHID VVYL HGYG WPRH KGGP MFYA STVG LPTV LEKL QKYY RQNP DIPQ LEPS DYLK KLAS QGNP PLKE WQSL AGSP SSKL |
Gene ID: | 1962 |
Uniprot: | Q08426 |
Cellular Location: | Peroxisome |
Calculated MW: | 69kDa/79kDa |
Observed MW: | 79kDa |
Synonyms: | EHHADH, ECHD, FRTS3, L-PBE, LBFP, LBP, PBFE |
Background: | The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | EHHADH: 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - lysine degradation; EC 5.3.3.8; Oxidoreductase; EC 4.2.1.17; Other Amino Acids Metabolism - beta-alanine; Lipid Metabolism - fatty acid; EC 1.1.1.35; Mitochondrial; Lyase; Isomerase; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - propanoate Chromosomal Location of Human Ortholog: 3q26.3-q28 Cellular Component: mitochondrion; peroxisome; cytosol Molecular Function:enzyme binding; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; coenzyme binding; 3-hydroxyacyl-CoA dehydrogenase activity; receptor binding Biological Process: fatty acid beta-oxidation; internal protein amino acid acetylation Disease: Fanconi Renotubular Syndrome 3 |
NCBI Summary: | The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q08426 |
NCBI GenInfo Identifier: | 223590229 |
NCBI Gene ID: | 1962 |
NCBI Accession: | Q08426.3 |
UniProt Secondary Accession: | Q08426,Q58EZ5, A8K6Y3, B4DWG3, D3DNU0, |
UniProt Related Accession: | Q08426 |
Molecular Weight: | 723 |
NCBI Full Name: | Peroxisomal bifunctional enzyme |
NCBI Synonym Full Names: | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase |
NCBI Official Symbol: | EHHADH |
NCBI Official Synonym Symbols: | LBP; ECHD; LBFP; PBFE; FRTS3; L-PBE |
NCBI Protein Information: | peroxisomal bifunctional enzyme; PBE; 3,2-trans-enoyl-CoA isomerase; peroxisomal enoyl-CoA hydratase; L-3-hydroxyacyl-CoA dehydrogenase; L-bifunctional protein, peroxisomal; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase |
UniProt Protein Name: | Peroxisomal bifunctional enzyme |
Protein Family: | Peroxisomal bifunctional enzyme |
UniProt Gene Name: | EHHADH |
UniProt Entry Name: | ECHP_HUMAN |