Epigenetics & Nuclear Signaling Antibodies 4
Anti-EHF Antibody (CAB7795)
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- SKU:
- CAB7795
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-EHF Antibody |
| Antibody SKU: | CAB7795 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human EHF (NP_036285.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human EHF (NP_036285.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MILE GGGV MNLN PGNN LLHQ PPAW TDSY STCN VSSG FFGG QWHE IHPQ YWTK YQVW EWLQ HLLD TNQL DANC IPFQ EFDI NGEH LCSM SLQE FTRA AGTA GQLL YSNL QHLK WNGQ CSSD LFQS THNV IVKT EQTE PSIM NTWK DENY LYDT NYGS TVDL LDSK TFCR AQIS MTTT SHLP VAES PDMK KEQD PPAK CHTK KHNP RGTH LW |
| Gene ID: | 26298 |
| Uniprot: | Q9NZC4 |
| Cellular Location: | Nucleus |
| Calculated MW: | 32kDa/34kDa/37kDa |
| Observed MW: | 35kDa |
| Synonyms: | EHF, ESE3, ESE3B, ESEJ |
| Background: | This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | EHF: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 11p12 Cellular Component: nucleoplasm; Golgi apparatus; nucleus Molecular Function:DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; cell proliferation; epithelial cell differentiation; multicellular organismal development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q9NZC4 |
| NCBI GenInfo Identifier: | 74762761 |
| NCBI Gene ID: | 26298 |
| NCBI Accession: | Q9NZC4.1 |
| UniProt Secondary Accession: | Q9NZC4,Q9H509, Q9UKF9, Q9Y5V4, Q9Y5V5, D3DR08, D3DR10 E9PSB2, |
| UniProt Related Accession: | Q9NZC4 |
| Molecular Weight: | 37,356 Da |
| NCBI Full Name: | ETS homologous factor |
| NCBI Synonym Full Names: | ets homologous factor |
| NCBI Official Symbol: | EHF |
| NCBI Official Synonym Symbols: | ESE3; ESEJ; ESE3B |
| NCBI Protein Information: | ETS homologous factor; EHF; hEHF; ESE3 transcription factor; ETS domain-containing transcription factor; epithelium-specific Ets transcription factor 3 |
| UniProt Protein Name: | ETS homologous factor |
| UniProt Synonym Protein Names: | ETS domain-containing transcription factor; Epithelium-specific Ets transcription factor 3; ESE-3 |
| Protein Family: | ETS homologous factor |
| UniProt Gene Name: | EHF |
| UniProt Entry Name: | EHF_HUMAN |
 | Western blot analysis of extracts of HT-29 cells, using EHF antibody (CAB7795) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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