Cell Biology Antibodies 12

Anti-EHBP1 Antibody (CAB9286)

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SKU:
CAB9286
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-EHBP1 Antibody
Antibody SKU:CAB9286
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human EHBP1 (NP_056067.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Jurkat, LO2, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human EHBP1 (NP_056067.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASV WKRL QRVG KHAS KFQF VASY QELM VECT KKWQ PDKL VVVW TRRS RRKS SKAH SWQP GIKN PYRG VVVW PVPE NIEI TVTL FKDP HAEE FEDK EWTF
Gene ID:23301
Uniprot:Q8NDI1
Cellular Location:Cytoplasm, Membrane
Calculated MW:132kDa/136kDa/140kDa
Observed MW:180kDa
Synonyms:EHBP1, HPC12, NACSIN
Background:This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:EHBP1: May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. Defects in EHBP1 are a cause of susceptibility to prostate cancer hereditary type 12 (HPC12). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: cytoplasm; plasma membrane

Disease: Prostate Cancer, Hereditary, 12

NCBI Summary:This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
UniProt Code:Q8NDI1
NCBI GenInfo Identifier:217330570
NCBI Gene ID:23301
NCBI Accession:NP_001136086.1
UniProt Secondary Accession:Q8NDI1,O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3 Q6QNV2, Q9NWI9,
UniProt Related Accession:Q8NDI1
Molecular Weight:Calculated MW: 140kDaMolecular Weight: 1231
NCBI Full Name:EH domain-binding protein 1 isoform 2
NCBI Synonym Full Names:EH domain binding protein 1
NCBI Official Symbol:EHBP1  
NCBI Official Synonym Symbols:HPC12; NACSIN  
NCBI Protein Information:EH domain-binding protein 1
UniProt Protein Name:EH domain-binding protein 1
Protein Family:EH domain-binding protein
UniProt Gene Name:EHBP1  
UniProt Entry Name:EHBP1_HUMAN
Anti-EHBP1 Polyclonal Antibody (CAB9286)Western blot analysis of extracts of various cell lines, using EHBP1 antibody (CAB9286) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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