Cardiovascular Antibodies
Anti-EGFL7 Antibody (CAB9376)
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- SKU:
- CAB9376
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-EGFL7 Antibody |
| Antibody SKU: | CAB9376 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-100 of human EGFL7 (NP_958854.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse heart, Mouse lung, Mouse kidney, Rat spleen, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-100 of human EGFL7 (NP_958854.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YRPG RRVC AVRA HGDP VSES FVQR VYQP FLTT CDGH RACS TYRT IYRT AYRR SPGL APAR PRYA CCPG WKRT SGLP G |
| Gene ID: | 51162 |
| Uniprot: | Q9UHF1 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 29kDa |
| Observed MW: | 30kDa |
| Synonyms: | EGFL7, NEU1, VE-STATIN, ZNEU1 |
| Background: | This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | EGFL7: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: extracellular matrix; extracellular space; extracellular region Molecular Function:calcium ion binding; Notch binding Biological Process: blood vessel development; negative regulation of Notch signaling pathway; positive regulation of endothelial cell proliferation; angiogenesis; cell adhesion; vasculogenesis; negative regulation of cell migration |
| NCBI Summary: | This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9UHF1 |
| NCBI GenInfo Identifier: | 92090985 |
| NCBI Gene ID: | 51162 |
| NCBI Accession: | Q9UHF1.3 |
| UniProt Secondary Accession: | Q9UHF1,Q5M7Y5, Q5VUD5, Q96EG0, B3KRP0, M9VTX9, |
| UniProt Related Accession: | Q9UHF1 |
| Molecular Weight: | 29,618 Da |
| NCBI Full Name: | Epidermal growth factor-like protein 7 |
| NCBI Synonym Full Names: | EGF-like-domain, multiple 7 |
| NCBI Official Symbol: | EGFL7 |
| NCBI Official Synonym Symbols: | NEU1; ZNEU1; VE-STATIN |
| NCBI Protein Information: | epidermal growth factor-like protein 7; EGF-like protein 7; NOTCH4-like protein; vascular endothelial statin; multiple EGF-like domains protein 7; multiple epidermal growth factor-like domains protein 7 |
| UniProt Protein Name: | Epidermal growth factor-like protein 7 |
| UniProt Synonym Protein Names: | Multiple epidermal growth factor-like domains protein 7; Multiple EGF-like domains protein 7; NOTCH4-like protein; Vascular endothelial statin; VE-statin; Zneu1 |
| Protein Family: | Epidermal growth factor-like protein |
| UniProt Gene Name: | EGFL7 |
| UniProt Entry Name: | EGFL7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EGFL7 antibody (CAB9376) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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