Cell Biology Antibodies 7

Anti-EFS Antibody (CAB16479)

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SKU:
CAB16479
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-EFS Antibody
Antibody SKU:CAB16479
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human EFS (NP_115835.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human EFS (NP_115835.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TALR VPSS GPYD CPAS FSHP LTRV APQP PGED DAPY DVPL TPKP PAEL EPDL EWEG GREP GPPI YAAP SNLK RASA LLNL YEAP EELL ADGE GGGT DEGI YDVP LLGP EAPP SPEP PGAL ASHD QDTL AQL
Gene ID:10278
Uniprot:O43281
Cellular Location:
Calculated MW:40kDa/48kDa/58kDa
Observed MW:75kDa
Synonyms:EFS, CAS3, CASS3, EFS1, EFS2, HEFS, SIN
Background:The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene.
UniProt Protein Function:EFS: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES. Belongs to the CAS family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytoplasm

Molecular Function:protein binding; protein domain specific binding

NCBI Summary:The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013]
UniProt Code:O43281
NCBI GenInfo Identifier:8134421
NCBI Gene ID:10278
NCBI Accession:O43281.1
UniProt Secondary Accession:O43281,O43282, B2RAJ7, B4DJ56, E9PGU2,
UniProt Related Accession:O43281
Molecular Weight:40,957 Da
NCBI Full Name:Embryonal Fyn-associated substrate
NCBI Synonym Full Names:embryonal Fyn-associated substrate
NCBI Official Symbol:EFS  
NCBI Official Synonym Symbols:SIN; CAS3; EFS1; EFS2; HEFS; CASS3  
NCBI Protein Information:embryonal Fyn-associated substrate
UniProt Protein Name:Embryonal Fyn-associated substrate
UniProt Synonym Protein Names:Cas scaffolding protein family member 3
Protein Family:Embryonal Fyn-associated substrate
UniProt Gene Name:EFS  
UniProt Entry Name:EFS_HUMAN
Anti-EFS Antibody (CAB16479)Western blot analysis of extracts of mouse thymus, using EFS antibody (CAB16479) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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