Cardiovascular Antibodies
Anti-EFNB2 Antibody (CAB12961)
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- SKU:
- CAB12961
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-EFNB2 Antibody |
| Antibody SKU: | CAB12961 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-229 of human EFNB2 (NP_004084.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-229 of human EFNB2 (NP_004084.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IVLE PIYW NSSN SKFL PGQG LVLY PQIG DKLD IICP KVDS KTVG QYEY YKVY MVDK DQAD RCTI KKEN TPLL NCAK PDQD IKFT IKFQ EFSP NLWG LEFQ KNKD YYII STSN GSLE GLDN QEGG VCQT RAMK ILMK VGQD ASSA GSTR NKDP TRRP ELEA GTNG RSST TSPF VKPN PGSS TDGN SAGH SGNN ILGS EVAL FA |
| Gene ID: | 1948 |
| Uniprot: | P52799 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 36kDa |
| Observed MW: | 50kDa |
| Synonyms: | EFNB2, EPLG5, HTKL, Htk-L, LERK5, ephrin-B2 |
| Background: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. |
| UniProt Protein Function: | EFNB2: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Membrane protein, integral Chromosomal Location of Human Ortholog: 13q33 Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane Molecular Function:protein binding; ephrin receptor binding Biological Process: axon guidance; organ morphogenesis; anatomical structure morphogenesis; regulation of chemotaxis; viral reproduction; cell-cell signaling; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; cell adhesion; lymph vessel development |
| NCBI Summary: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52799 |
| NCBI GenInfo Identifier: | 1706673 |
| NCBI Gene ID: | 1948 |
| NCBI Accession: | P52799.1 |
| UniProt Secondary Accession: | P52799,Q5JV56, |
| UniProt Related Accession: | P52799 |
| Molecular Weight: | 333 |
| NCBI Full Name: | Ephrin-B2 |
| NCBI Synonym Full Names: | ephrin-B2 |
| NCBI Official Symbol: | EFNB2 |
| NCBI Official Synonym Symbols: | HTKL; EPLG5; Htk-L; LERK5 |
| NCBI Protein Information: | ephrin-B2; LERK-5; HTK ligand; ligand of eph-related kinase 5; eph-related receptor tyrosine kinase ligand 5 |
| UniProt Protein Name: | Ephrin-B2 |
| UniProt Synonym Protein Names: | EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNB2 |
| UniProt Entry Name: | EFNB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EFNB2 antibody (CAB12961) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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