Developmental Biology
Anti-EFNB1 Antibody (CAB2518)
- SKU:
- CAB2518
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-EFNB1 Antibody |
| Antibody SKU: | CAB2518 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-237 of human EFNB1 (NP_004420.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, NCI-H460, Mouse lung, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-237 of human EFNB1 (NP_004420.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LAKN LEPV SWSS LNPK FLSG KGLV IYPK IGDK LDII CPRA EAGR PYEY YKLY LVRP EQAA ACST VLDP NVLV TCNR PEQE IRFT IKFQ EFSP NYMG LEFK KHHD YYIT STSN GSLE GLEN REGG VCRT RTMK IIMK VGQD PNAV TPEQ LTTS RPSK EADN TVKM ATQA PGSR GSLG DSDG KHET VNQE EKSG PGAS GGSS GDPD GFFN SK |
| Gene ID: | 1947 |
| Uniprot: | P98172 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 38kDa |
| Observed MW: | 42kDa |
| Synonyms: | EFNB1, CFND, CFNS, EFB1, EFL3, EPLG2, Elk-L, LERK2, ephrin-B1 |
| Background: | The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. |
| UniProt Protein Function: | EFNB1: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphB1 and EphA1. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B1 may play a role in cell adhesion and functions in the development or maintenance of the nervous system. Binding to its receptor induces the collapse of commissural axons/growth cones in vitro. Induced by TNF-alpha. Expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Ligand, receptor tyrosine kinase Chromosomal Location of Human Ortholog: Xq12 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; synapse; nucleus; lipid raft Molecular Function:protein binding; ephrin receptor binding Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway; positive regulation of T cell proliferation; cell adhesion; embryonic pattern specification; neural crest cell migration Disease: Craniofrontonasal Syndrome |
| NCBI Summary: | The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P98172 |
| NCBI GenInfo Identifier: | 1706668 |
| NCBI Gene ID: | 1947 |
| NCBI Accession: | P98172.1 |
| UniProt Secondary Accession: | P98172,D3DVU0, |
| UniProt Related Accession: | P98172 |
| Molecular Weight: | 346 |
| NCBI Full Name: | Ephrin-B1 |
| NCBI Synonym Full Names: | ephrin-B1 |
| NCBI Official Symbol: | EFNB1 |
| NCBI Official Synonym Symbols: | CFND; CFNS; EFB1; EFL3; EPLG2; Elk-L; LERK2 |
| NCBI Protein Information: | ephrin-B1; EFL-3; LERK-2; ELK ligand; ligand of eph-related kinase 2; eph-related receptor tyrosine kinase ligand 2 |
| UniProt Protein Name: | Ephrin-B1 |
| UniProt Synonym Protein Names: | EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2 |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNB1 |
| UniProt Entry Name: | EFNB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EFNB1 antibody (CAB2518) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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