Cell Biology Antibodies 8

Anti-EFNA3 Antibody (CAB2724)

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SKU:
CAB2724
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-EFNA3 Antibody
Antibody SKU:CAB2724
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-214 of human EFNA3 (NP_004943.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Mouse
Positive Samples:Mouse brain, Mouse spinal cord, Mouse skeletal muscle
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-214 of human EFNA3 (NP_004943.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QGPG GALG NRHA VYWN SSNQ HLRR EGYT VQVN VNDY LDIY CPHY NSSG VGPG AGPG PGGG AEQY VLYM VSRN GYRT CNAS QGFK RWEC NRPH APHS PIKF SEKF QRYS AFSL GYEF HAGH EYYY ISTP THNL HWKC LRMK VFVC CAST SHSG EKPV PTLP QFTM GPNV KINV LEDF EGEN PQVP KLEK SISG
Gene ID:1944
Uniprot:P52797
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:23kDa/26kDa
Observed MW:30kDa
Synonyms:EFNA3, EFL2, EPLG3, Ehk1-L, LERK3, ephrin-A3
Background:This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin.
UniProt Protein Function:EFNA3: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Belongs to the ephrin family.
UniProt Protein Details:

Protein type:Ligand, receptor tyrosine kinase; Cell development/differentiation; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: integral to plasma membrane; extracellular region; plasma membrane

Molecular Function:ephrin receptor binding; transmembrane-ephrin receptor activity

Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway

NCBI Summary:This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]
UniProt Code:P52797
NCBI GenInfo Identifier:1706671
NCBI Gene ID:1944
NCBI Accession:P52797.1
UniProt Secondary Accession:P52797,Q0VGC9, Q5SR70, B7ZAD3, D3DV85,
UniProt Related Accession:P52797
Molecular Weight:23,575 Da
NCBI Full Name:Ephrin-A3
NCBI Synonym Full Names:ephrin-A3
NCBI Official Symbol:EFNA3  
NCBI Official Synonym Symbols:EFL2; EPLG3; LERK3; Ehk1-L  
NCBI Protein Information:ephrin-A3; EFL-2; EHK1 ligand; LERK-3; eph-related receptor tyrosine kinase ligand 3; ligand of eph-related kinase 3
UniProt Protein Name:Ephrin-A3
UniProt Synonym Protein Names:EFL-2; EHK1 ligand; EHK1-L; EPH-related receptor tyrosine kinase ligand 3; LERK-3
Protein Family:Ephrin
UniProt Gene Name:EFNA3  
UniProt Entry Name:EFNA3_HUMAN
Anti-EFNA3 Antibody (CAB2724)Western blot analysis of extracts of various cell lines, using EFNA3 antibody (CAB2724) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
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