Cardiovascular Antibodies
Anti-EDG1 Antibody (CAB3997)
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- SKU:
- CAB3997
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-EDG1 Antibody |
| Antibody SKU: | CAB3997 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human EDG1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, A375, HUVEC, Mouse lung, Mouse brain, Mouse spleen, Rat lung, Rat heart |
| Immunogen: | A synthesized peptide derived from human EDG1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1901 |
| Uniprot: | P21453 |
| Cellular Location: | |
| Calculated MW: | 43kDa |
| Observed MW: | 45KDa |
| Synonyms: | CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1 |
| Background: | The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Protein Function: | EDG-1: a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 1p21.2 Cellular Component: intracellular membrane-bound organelle; intrinsic to plasma membrane; nucleoplasm; plasma membrane Molecular Function:G-protein coupled receptor activity; G-protein-coupled receptor binding Biological Process: actin cytoskeleton reorganization; blood vessel maturation; cell adhesion; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; lamellipodium biogenesis; regulation of bone mineralization; regulation of bone resorption |
| NCBI Summary: | The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P21453 |
| NCBI GenInfo Identifier: | 205371820 |
| NCBI Gene ID: | 1901 |
| NCBI Accession: | P21453.2 |
| UniProt Secondary Accession: | P21453,Q9BYY4, Q9NYN8, D3DT66, |
| UniProt Related Accession: | P21453 |
| Molecular Weight: | |
| NCBI Full Name: | Sphingosine 1-phosphate receptor 1 |
| NCBI Synonym Full Names: | sphingosine-1-phosphate receptor 1 |
| NCBI Official Symbol: | S1PR1 |
| NCBI Official Synonym Symbols: | EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362 |
| NCBI Protein Information: | sphingosine 1-phosphate receptor 1 |
| UniProt Protein Name: | Sphingosine 1-phosphate receptor 1 |
| UniProt Synonym Protein Names: | Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD_antigen: CD363 |
| Protein Family: | Sphingosine 1-phosphate receptor |
| UniProt Gene Name: | S1PR1 |
 | Western blot - EDG1 Rabbit mAb (CAB3997) |
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