Cell Biology Antibodies 4

Anti-EDC3 Antibody (CAB13763)

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SKU:
CAB13763
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-EDC3 Antibody
Antibody SKU:CAB13763
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 159-508 of human EDC3 (NP_079359.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, MCF7, HeLa, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 159-508 of human EDC3 (NP_079359.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HNSW SSSS RHPN QATP KKSG LKNG QMKN KDDE CFGD DIEE IPDT DFDF EGNL ALFD KAAV FEEI DTYE RRSG TRSR GIPN ERPT RYRH DENI LESE PIVY RRII VPHN VSKE FCTD SGLV VPSI SYEL HKKL LSVA EKHG LTLE RRLE MTGV CASQ MALT LLGG PNRL NPKN VHQR PTVA LLCG PHVK GAQG ISCG RHLA NHDV QVIL FLPN FVKM LESI TNEL SLFS KTQG QQVS SLKD LPTS PVDL VINC LDCP ENVF LRDQ PWYK AAVA WANQ NRAP VLSI DPPV HEVE QGID AKWS LALG LPLP LGEH AGRI YLCD IGIP QQVF QEVG INYH SPFG CKFV IPLH SA
Gene ID:80153
Uniprot:Q96F86
Cellular Location:Cytoplasm, P-body
Calculated MW:56kDa
Observed MW:56kDa
Synonyms:EDC3, LSM16, MRT50, YJDC, YJEFN2
Background:
UniProt Protein Function:EDC3: Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis. Belongs to the EDC3 family.
UniProt Protein Details:

Protein type:RNA processing

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: membrane; cytosol

Molecular Function:identical protein binding; protein binding; RNA binding

Biological Process: gene expression; mRNA catabolic process, deadenylation-dependent decay

Disease: Mental Retardation, Autosomal Recessive 50

NCBI Summary:EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008]
UniProt Code:Q96F86
NCBI GenInfo Identifier:74731669
NCBI Gene ID:80153
NCBI Accession:Q96F86.1
UniProt Secondary Accession:Q96F86,Q9H797, B3KPH0, D3DW61,
UniProt Related Accession:Q96F86
Molecular Weight:508
NCBI Full Name:Enhancer of mRNA-decapping protein 3
NCBI Synonym Full Names:enhancer of mRNA decapping 3
NCBI Official Symbol:EDC3  
NCBI Official Synonym Symbols:YJDC; LSM16; YJEFN2  
NCBI Protein Information:enhancer of mRNA-decapping protein 3; yjeF_N2; hYjeF_N2; hYjeF_N2-15q23; yjeF domain containing; yjeF domain-containing protein 1; LSM16 homolog (EDC3, S. cerevisiae); enhancer of mRNA decapping 3 homolog; yjeF N-terminal domain-containing protein 2
UniProt Protein Name:Enhancer of mRNA-decapping protein 3
UniProt Synonym Protein Names:LSM16 homolog; YjeF N-terminal domain-containing protein 2; YjeF_N2; hYjeF_N2; YjeF domain-containing protein 1
Protein Family:Enhancer of mRNA-decapping protein
UniProt Gene Name:EDC3  
UniProt Entry Name:EDC3_HUMAN
Anti-EDC3 Antibody (CAB13763)Western blot analysis of extracts of various cell lines, using EDC3 antibody (CAB13763) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-EDC3 Antibody (CAB13763)Immunohistochemistry of paraffin-embedded rat brain using EDC3 antibody (CAB13763) at dilution of 1:150 (40x lens).
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