Cell Death Antibodies 1
Anti-EDAR Antibody (CAB14105)
(No reviews yet)
Write a Review
- SKU:
- CAB14105
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-EDAR Antibody |
| Antibody SKU: | CAB14105 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-187 of human EDAR (NP_071731.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-187 of human EDAR (NP_071731.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EYSN CGEN EYYN QTTG LCQE CPPC GPGE EPYL SCGY GTKD EDYG CVPC PAEK FSKG GYQI CRRH KDCE GFFR ATVL TPGD MEND AECG PCLP GYYM LENR PRNI YGMV CYSC LLAP PNTK ECVG ATSG ASAN FPGT SGSS TLSP FQHA HKEL SGQG HLAT A |
| Gene ID: | 10913 |
| Uniprot: | Q9UNE0 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 48kDa/51kDa |
| Observed MW: | 48kDa |
| Synonyms: | EDAR, DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, HRM1 |
| Background: | This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. |
| UniProt Protein Function: | EDAR: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3); also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 2q13 Cellular Component: apical part of cell; plasma membrane; integral to membrane Molecular Function:protein binding; transmembrane receptor activity; receptor activity Biological Process: epidermis development; pigmentation; hair follicle development; apoptosis; positive regulation of NF-kappaB import into nucleus; cell differentiation; signal transduction; odontogenesis of dentine-containing teeth Disease: Hair Morphology 1; Ectodermal Dysplasia 10a, Hypohidrotic/hair/nail Type, Autosomal Dominant; Ectodermal Dysplasia 10b, Hypohidrotic/hair/tooth Type, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UNE0 |
| NCBI GenInfo Identifier: | 21263572 |
| NCBI Gene ID: | 10913 |
| NCBI Accession: | Q9UNE0.1 |
| UniProt Related Accession: | Q9UNE0 |
| Molecular Weight: | |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member EDAR |
| NCBI Synonym Full Names: | ectodysplasin A receptor |
| NCBI Official Symbol: | EDAR |
| NCBI Official Synonym Symbols: | DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member EDAR |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member EDAR |
| UniProt Synonym Protein Names: | Anhidrotic ectodysplasin receptor 1; Downless homolog; EDA-A1 receptor; Ectodermal dysplasia receptor; Ectodysplasin-A receptor |
| Protein Family: | Tumor necrosis factor receptor superfamily |
| UniProt Gene Name: | EDAR |
| UniProt Entry Name: | EDAR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EDAR antibody (CAB14105) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
View AllClose
Related Products
Anti-EDAR Antibody (CAB4461)
Cell Death Antibodies 2
OverviewProduct Name:EDAR Rabbit pAbProduct Code:CAB4461Size:20uL, 50uL, 100uLSynonyms:EDAR, DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A
![EDAR Monoclonal Antibody [PAT19E8AT] (CPAB0624)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58844/64026/edar-monoclonal-antibody-pat19e8at-cpab0624__92836__08373.1706535234.jpg?c=1 "EDAR Monoclonal Antibody [PAT19E8AT] (CPAB0624)")
Human EDAR/DL Recombinant Protein (RPES0982)
system_update_altDatasheetHuman EDAR/DL Recombinant Protein Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in si
Rat EDAR/DL Recombinant Protein (RPES4847)
system_update_altDatasheetRat EDAR/DL Recombinant Protein Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in sign
Mouse EDAR/DL Recombinant Protein (RPES0438)
system_update_altDatasheetMouse EDAR/DL Recombinant Protein Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF-? receptor superfamily which plays a key role in ectoderma
Human EDAR/DL Recombinant Protein (RPES0963)
system_update_altDatasheetHuman EDAR/DL Recombinant Protein Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in si
