Anti-EBI3 Antibody (CAB19613)

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SKU:
CAB19613
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IL-27B
Synonyms:
IL27B
Synonyms:
IL35B

Description

Product Name:EBI3 Rabbit mAb
Product Code:CAB19613
Size:20uL, 50uL, 100uL
Synonyms:IL-27B, IL27B, IL35B
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human EBI3
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, Mouse spleen, Rat brain
Immunogen:A synthesized peptide derived from human EBI3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10148
Uniprot:Q14213
Calculated MW:25kDa
Observed MW:34KDa
UniProt Protein Function:IL27-beta: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Belongs to the type I cytokine receptor family. Type 3 subfamily.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular region; extracellular space; plasma membrane

Molecular Function:cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-27 receptor binding; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; humoral immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of interferon-gamma biosynthetic process; T cell proliferation; T-helper 1 type immune response

NCBI Summary:This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
UniProt Code:Q14213
NCBI GenInfo Identifier:47605806
NCBI Gene ID:10148
NCBI Accession:Q14213.2
UniProt Secondary Accession:Q14213,O75269, A0N0N2,
UniProt Related Accession:Q14213
Molecular Weight:25,396 Da
NCBI Full Name:Interleukin-27 subunit beta
NCBI Synonym Full Names:Epstein-Barr virus induced 3
NCBI Official Symbol:EBI3  
NCBI Official Synonym Symbols:IL27B; IL-27B  
NCBI Protein Information:interleukin-27 subunit beta
UniProt Protein Name:Interleukin-27 subunit beta
UniProt Synonym Protein Names:Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein
Protein Family:Interleukin
UniProt Gene Name:EBI3  
UniProt Entry Name:IL27B_HUMAN
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