Signal Transduction Antibodies 3

Anti-EAAT2 Antibody (CAB3679)

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SKU:
CAB3679
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-EAAT2 Antibody
Antibody SKU:CAB3679
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human EAAT2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, U-87MG, Y79, Mouse liver, Mouse brain, Mouse eye, Rat liver, Rat brain
Immunogen:A synthesized peptide derived from human EAAT2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6506
Uniprot:P43004
Cellular Location:
Calculated MW:62kDa
Observed MW:70KDa
Synonyms:EAAT2, EIEE41, GLT-1, HBGT
Background:This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]
UniProt Protein Function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
NCBI Summary:This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]
UniProt Code:P43004
NCBI GenInfo Identifier:3041668
NCBI Gene ID:6506
NCBI Accession:P43004.2
UniProt Secondary Accession:P43004,Q14417, Q541G6, B4DQE9, U3KQQ4,
UniProt Related Accession:P43004
Molecular Weight:61,008 Da
NCBI Full Name:Excitatory amino acid transporter 2
NCBI Synonym Full Names:solute carrier family 1 member 2
NCBI Official Symbol:SLC1A2  
NCBI Official Synonym Symbols:HBGT; EAAT2; GLT-1  
NCBI Protein Information:excitatory amino acid transporter 2
UniProt Protein Name:Excitatory amino acid transporter 2
UniProt Synonym Protein Names:Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2
Protein Family:Excitatory amino acid transporter
UniProt Gene Name:SLC1A2  
UniProt Entry Name:EAA2_HUMAN
Anti-EAAT2 Antibody (CAB3679)Western blot - EAAT2 Rabbit mAb (CAB3679)
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