Anti-EAAT1/SLC1A3 Antibody (CAB9712)
- SKU:
- CAB9712
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EA6
- Synonyms:
- EAAT1
- Synonyms:
- GLAST
- Synonyms:
- GLAST1
Description
| Product Name: | EAAT1/SLC1A3 Rabbit mAb |
| Product Code: | CAB9712 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | EA6, EAAT1, GLAST, GLAST1 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human EAAT1/SLC1A3 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human EAAT1/SLC1A3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6507 |
| Uniprot: | P43003 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 59kDa |
| Observed MW: | 50-55kDa, 90-150kDa, 58kDa/130kDa |
| UniProt Protein Function: | SLC1A3: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial; Transporter, SLC family; Transporter Chromosomal Location of Human Ortholog: 5p13 Cellular Component: membrane; plasma membrane Molecular Function:amino acid transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity Biological Process: glutamate secretion; ion transport; L-glutamate import; neurotransmitter uptake; positive regulation of defense response to virus by host; synaptic transmission Disease: Episodic Ataxia, Type 6 |
| NCBI Summary: | This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014] |
| UniProt Code: | P43003 |
| NCBI GenInfo Identifier: | 262359914 |
| NCBI Gene ID: | 6507 |
| NCBI Accession: | NP_001160167.1 |
| UniProt Secondary Accession: | P43003,Q4JCQ8, B2R5T3, |
| UniProt Related Accession: | P43003 |
| Molecular Weight: | |
| NCBI Full Name: | excitatory amino acid transporter 1 isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 1 member 3 |
| NCBI Official Symbol: | SLC1A3 |
| NCBI Official Synonym Symbols: | EA6; EAAT1; GLAST; GLAST1 |
| NCBI Protein Information: | excitatory amino acid transporter 1 |
| UniProt Protein Name: | Excitatory amino acid transporter 1 |
| UniProt Synonym Protein Names: | Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 |
| Protein Family: | Excitatory amino acid transporter |
| UniProt Gene Name: | SLC1A3 |
| UniProt Entry Name: | EAA1_HUMAN |
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