Anti-E2F2 Antibody (CAB3297)
- SKU:
- CAB3297
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- E2F-2
- Research Area:
- Cell Cycle
Description
| Product Name: | E2F2 Rabbit mAb |
| Product Code: | CAB3297 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | E2F-2 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human E2F2 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, SH-SY5Y, Mouse lung, Mouse thymus |
| Immunogen: | A synthesized peptide derived from human E2F2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1870 |
| Uniprot: | Q14209 |
| Calculated MW: | 47kDa |
| Observed MW: | 50kDa |
| UniProt Protein Function: | E2F2: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Belongs to the E2F/DP family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p36 Cellular Component: nucleoplasm; transcription factor complex Molecular Function:protein binding; DNA binding; transcription factor binding; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle |
| NCBI Summary: | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14209 |
| NCBI GenInfo Identifier: | 2494228 |
| NCBI Gene ID: | 1870 |
| NCBI Accession: | Q14209.1 |
| UniProt Secondary Accession: | Q14209,Q7Z6H1, B2R9W1, |
| UniProt Related Accession: | Q14209 |
| Molecular Weight: | 47,506 Da |
| NCBI Full Name: | Transcription factor E2F2 |
| NCBI Synonym Full Names: | E2F transcription factor 2 |
| NCBI Official Symbol: | E2F2 |
| NCBI Official Synonym Symbols: | E2F-2 |
| NCBI Protein Information: | transcription factor E2F2 |
| UniProt Protein Name: | Transcription factor E2F2 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | E2F2 |
| UniProt Entry Name: | E2F2_HUMAN |
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