Anti-E2F2 Antibody (CAB3297)

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SKU:
CAB3297
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
E2F-2
Research Area:
Cell Cycle

Description

Product Name:E2F2 Rabbit mAb
Product Code:CAB3297
Size:20uL, 50uL, 100uL
Synonyms:E2F-2
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human E2F2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, SH-SY5Y, Mouse lung, Mouse thymus
Immunogen:A synthesized peptide derived from human E2F2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1870
Uniprot:Q14209
Calculated MW:47kDa
Observed MW:50kDa
UniProt Protein Function:E2F2: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Belongs to the E2F/DP family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function:protein binding; DNA binding; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle

NCBI Summary:The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
UniProt Code:Q14209
NCBI GenInfo Identifier:2494228
NCBI Gene ID:1870
NCBI Accession:Q14209.1
UniProt Secondary Accession:Q14209,Q7Z6H1, B2R9W1,
UniProt Related Accession:Q14209
Molecular Weight:47,506 Da
NCBI Full Name:Transcription factor E2F2
NCBI Synonym Full Names:E2F transcription factor 2
NCBI Official Symbol:E2F2  
NCBI Official Synonym Symbols:E2F-2  
NCBI Protein Information:transcription factor E2F2
UniProt Protein Name:Transcription factor E2F2
Protein Family:Transcription factor
UniProt Gene Name:E2F2  
UniProt Entry Name:E2F2_HUMAN
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