Cell Cycle Antibodies 1

Anti-E2F2 Antibody (CAB16367)

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SKU:
CAB16367
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-E2F2 Antibody
Antibody SKU:CAB16367
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human E2F2 (NP_004082.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human E2F2 (NP_004082.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VYLC PEEV QEPD SPSE EPLP STST LCPS PDSA QPSS STDP SIME PTAS SVPA PAPT PQQA PPPP SLVP LEAT DSLL ELPH PLLQ QTED QFLS PTLA CSSP LISF SPSL DQDD YLWG LEAG EGIS DLFD SYDL GDLL IN
Gene ID:1870
Uniprot:Q14209
Cellular Location:Nucleus
Calculated MW:47kDa
Observed MW:Refer to figures
Synonyms:E2F2, E2F-2
Background:The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.
UniProt Protein Function:E2F2: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Belongs to the E2F/DP family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function:protein binding; DNA binding; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle

NCBI Summary:The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
UniProt Code:Q14209
NCBI GenInfo Identifier:2494228
NCBI Gene ID:1870
NCBI Accession:Q14209.1
UniProt Secondary Accession:Q14209,Q7Z6H1, B2R9W1,
UniProt Related Accession:Q14209
Molecular Weight:47,506 Da
NCBI Full Name:Transcription factor E2F2
NCBI Synonym Full Names:E2F transcription factor 2
NCBI Official Symbol:E2F2  
NCBI Official Synonym Symbols:E2F-2  
NCBI Protein Information:transcription factor E2F2
UniProt Protein Name:Transcription factor E2F2
Protein Family:Transcription factor
UniProt Gene Name:E2F2  
UniProt Entry Name:E2F2_HUMAN
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